Acylcarnitines: reflecting or inflicting insulin resistance? (Q27004603)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258903%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

review article

2 references

2 October 2023

Acylcarnitines: reflecting or inflicting insulin resistance? (English)

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21 February 2020

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15 August 2020

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21 February 2020

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21 February 2020

Marieke G Schooneman

1 reference

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21 February 2020

Frédéric M Vaz

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21 February 2020

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1 January 2013

7 references

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7 November 2019

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21 February 2020

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21 February 2020

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21 February 2020

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21 February 2020

6 references

24 March 2019

20 June 2019

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7 November 2019

15 August 2020

2 October 2023

ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected]

1 reference

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

21 March 2017

1 reference

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 March 2017

1 reference

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Human metabolic individuality in biomedical and pharmaceutical research

21 March 2017

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

21 March 2017

1 reference

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Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women

21 March 2017

1 reference

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CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity

21 March 2017

1 reference

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 March 2017

1 reference

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Mechanisms for insulin resistance: common threads and missing links

7 April 2017

1 reference

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Metabolite profiles and the risk of developing diabetes

7 April 2017

1 reference

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Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

7 April 2017

1 reference

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Cellular mechanisms of insulin resistance

7 April 2017

1 reference

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Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity

7 April 2017

1 reference

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Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility

28 September 2017

1 reference

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Lipid-induced mitochondrial stress and insulin action in muscle

28 September 2017

1 reference

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Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS.

28 September 2017

1 reference

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Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity

28 September 2017

1 reference

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Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women

28 September 2017

1 reference

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Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.

28 September 2017

1 reference

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Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects

28 September 2017

1 reference

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Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.

28 September 2017

1 reference

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Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity

28 September 2017

1 reference

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Metabolomics applied to diabetes research: moving from information to knowledge

28 September 2017

1 reference

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Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control

28 September 2017

1 reference

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The Randle cycle revisited: a new head for an old hat.

28 September 2017

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Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women

28 September 2017

1 reference

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Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.

28 September 2017

1 reference

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High heritability of metabolomic profiles in families burdened with premature cardiovascular disease

28 September 2017

1 reference

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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

28 September 2017

1 reference

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Lipid mediators of insulin resistance

28 September 2017

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Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns

28 September 2017

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Interactions of acyl carnitines with model membranes: a (13)C-NMR study

28 September 2017

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Control of mitochondrial beta-oxidation flux

28 September 2017

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Carnitine biosynthesis in mammals

28 September 2017

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Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux

28 September 2017

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Molecular enzymology of carnitine transfer and transport

28 September 2017

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Intramuscular lipid content is increased in obesity and decreased by weight loss

28 September 2017

1 reference

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The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function

28 September 2017

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Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate

28 September 2017

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Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor

28 September 2017

1 reference

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Regulation of fatty acid oxidation in the mammalian heart in health and disease

28 September 2017

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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis

28 September 2017

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Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A a

28 September 2017

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Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats.

28 September 2017

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Insulin stimulates L-carnitine accumulation in human skeletal muscle

31 May 2018

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Dynamic changes of plasma acylcarnitine levels induced by fasting and sunflower oil challenge test in children

31 May 2018

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31 May 2018

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Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over beta-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states

31 May 2018

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Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine

31 May 2018

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Quantitation of the efflux of acylcarnitines from rat heart, brain, and liver mitochondria

31 May 2018

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Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-induced metabolite

31 May 2018

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Muscle acylcarnitines during short-term fasting in lean healthy men.

28 November 2018

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Quantification of carnitine and acylcarnitines in biological matrices by HPLC electrospray ionization-mass spectrometry

28 November 2018

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Acylcarnitine profile analysis

28 November 2018

1 reference

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Lipid-induced metabolic dysfunction in skeletal muscle.

28 November 2018

1 reference

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PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation

28 November 2018

1 reference

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Elevated Free Fatty Acids Attenuate the Insulin-Induced Suppression of PDK4 Gene Expression in Human Skeletal Muscle: Potential Role of Intramuscular Long-Chain Acyl-Coenzyme A

28 November 2018

1 reference

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Carnitine revisited: potential use as adjunctive treatment in diabetes.

28 November 2018

1 reference

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A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans.

28 November 2018

1 reference

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An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle

28 November 2018

1 reference

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Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

28 November 2018

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Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation

28 November 2018

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Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

28 November 2018

1 reference

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Reconstitution into liposomes and functional characterization of the carnitine transporter from renal cell plasma membrane

28 November 2018

1 reference

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Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

28 November 2018

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Effect of weight loss on muscle lipid content in morbidly obese subjects

28 November 2018

1 reference

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Validation of an ESI-MS/MS screening method for acylcarnitine profiling in urine specimens of neonates, children, adolescents and adults

28 November 2018

1 reference

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Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

28 November 2018

1 reference

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Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

28 November 2018

1 reference

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Skeletal muscle triglyceride levels are inversely related to insulin action

28 November 2018

1 reference

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Carnitine metabolism in normal-weight and obese human subjects during fasting

28 November 2018

1 reference

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Carnitine metabolism in Macaca arctoides: the effects of dietary change and fasting on serum triglycerides, unesterified carnitine, esterified (acyl) carnitine, and beta-hydroxybutyrate

28 November 2018

1 reference

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Carnitine deficiency in diabetes mellitus complications

28 November 2018

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12 December 2020

Lipid oxidation is reduced in obese human skeletal muscle

1 reference

12 December 2020

The association of acetyl-L-carnitine with glucose and lipid metabolism in human muscle in vivo: the effect of hyperinsulinemia

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12 December 2020

Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha

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12 December 2020

Determination of free L-carnitine levels in type II diabetic women with and without complications

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12 December 2020

Identifiers

DOI

10.2337/DB12-0466

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258903%20AND%20SRC:MED&resulttype=core&format=json

release_uixrhn2e5jesvm2ofhwqpk4igq

21 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uixrhn2e5jesvm2ofhwqpk4igq

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258903%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

23258903

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23258903%20AND%20SRC:MED&resulttype=core&format=json