PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis (Q26992267)

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English	PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis	scientific article

Statements

scholarly article

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systematic review

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based on heuristic

inferred from title

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based on heuristic

inferred from title

PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis (English)

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colorectal cancer

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based on heuristic

inferred from title

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based on heuristic

inferred from title

systematic review

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based on heuristic

inferred from title

metastatic colon cancer

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based on heuristic

inferred from title

colorectal carcinoma

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based on heuristic

inferred from title

monoclonal antibody

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based on heuristic

inferred from title

author name string

C. Mao

1

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Z. Y. Yang

2

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X. F. Hu

3

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Q. Chen

4

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J. L. Tang

5

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language of work or name

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publication date

June 2012

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Annals of Oncology

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23

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6

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1518-25

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Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

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Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

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Systemic therapy for colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

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The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer.

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer.

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

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Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in ≥ 2 line cetuximab-based therapy of colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Statistical aspects of the analysis of data from retrospective studies of disease

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

PIK3CA mutation associates with improved outcome in breast cancer.

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Meta-analysis in clinical trials

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Bias in meta-analysis detected by a simple, graphical test

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Misleading funnel plot for detection of bias in meta-analysis

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Testing for qualitative interactions between treatment effects and patient subsets

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: a meta-analysis of 22 studies

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1093%2FANNONC%2FMDR464

21 January 2018

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