Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms (Q26995624)

Immunology and Allergy Clinics of North America

published in

1 reference

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219-37

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Developmental origin and functional specialization of mast cell subsets

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MiR-221 influences effector functions and actin cytoskeleton in mast cells

21 March 2017

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Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

21 March 2017

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MicroRNA-221-222 regulate the cell cycle in mast cells

21 March 2017

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Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

21 March 2017

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p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis

21 March 2017

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Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

21 March 2017

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 March 2017

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SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

21 March 2017

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 March 2017

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Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand

21 March 2017

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Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis

21 March 2017

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Expression and function of c-kit in hemopoietic progenitor cells

21 March 2017

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Structure of a c-kit product complex reveals the basis for kinase transactivation

21 March 2017

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Stem cell factor and its receptor c-Kit as targets for inflammatory diseases

21 March 2017

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Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

21 March 2017

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The phosphoinositide (PI) 3-kinase family

21 March 2017

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Oncogenic kinase signalling

21 March 2017

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Early signaling pathways activated by c-Kit in hematopoietic cells

21 March 2017

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Stem cell factor receptor/c-Kit: from basic science to clinical implications

21 March 2017

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Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells

21 March 2017

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Signal transduction via the stem cell factor receptor/c-Kit

21 March 2017

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Lyn Associates with the Juxtamembrane Region of c-Kit and Is Activated by Stem Cell Factor in Hematopoietic Cell Lines and Normal Progenitor Cells

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Stem cell factor and hematopoiesis

21 March 2017

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Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms

21 March 2017

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Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma

21 March 2017

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Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

21 March 2017

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Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Kit receptor dimerization is driven by bivalent binding of stem cell factor

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Endocytosis and signalling: intertwining molecular networks

21 March 2017

1 reference

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Emerging Evidence for MicroRNAs as Regulators of Cancer Stem Cells

7 April 2017

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A critical review of trials of first-line BCR-ABL inhibitor treatment in patients with newly diagnosed chronic myeloid leukemia in chronic phase

28 September 2017

1 reference

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A gist of gastrointestinal stromal tumors: A review

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia

28 September 2017

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Metabolism of inflammation limited by AMPK and pseudo-starvation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

New models for analyzing mast cell functions in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Therapeutic targeting of c-KIT in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Differential regulation of transcription factors by location-specific EGF receptor signaling via a spatio-temporal interplay of ERK activation

28 September 2017

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Allosteric communication across the native and mutated KIT receptor tyrosine kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Targeting the KIT activating switch control pocket: a novel mechanism to inhibit neoplastic mast cell proliferation and mast cell activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Expression and mutation of the c-kit gene and correlation with prognosis of small cell lung cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

28 September 2017

1 reference

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ERK1/2 MAP kinases: structure, function, and regulation

28 September 2017

1 reference

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A potential role for nilotinib in KIT-mutated melanoma

28 September 2017

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RNA-based therapeutics: current progress and future prospects.

28 September 2017

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Tyrosine kinase inhibitors in the treatment of systemic mastocytosis.

28 September 2017

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Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet?

28 September 2017

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KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

28 September 2017

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New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases

28 September 2017

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Human mast cells and mastocytosis: harnessing microRNA expression as a new approach to therapy?

28 September 2017

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First-line therapy for chronic myeloid leukemia: new horizons and an update

28 September 2017

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Clinical implications of c-Kit mutations in acute myelogenous leukemia.

28 September 2017

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F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation.

28 September 2017

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Targeting the RAF-MEK-ERK pathway in cancer therapy

28 September 2017

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Mast cells and mastocytosis

28 September 2017

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Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders

28 September 2017

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MicroRNAs accurately identify cancer tissue origin

28 September 2017

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Late endosomal traffic of the epidermal growth factor receptor ensures spatial and temporal fidelity of mitogen-activated protein kinase signaling

28 September 2017

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Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder

28 September 2017

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Lipid rafts are required for Kit survival and proliferation signals

28 September 2017

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Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling

28 September 2017

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Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Molecular mechanisms of mast cell development

28 September 2017

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Tyrphostins and other tyrosine kinase inhibitors

28 September 2017

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Molecular regulation of mast cell activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Integrated signalling pathways for mast-cell activation

28 September 2017

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Normal and oncogenic forms of the receptor tyrosine kinase kit.

28 September 2017

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KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.

28 September 2017

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Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway

28 September 2017

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Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

28 September 2017

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The odd couple: signal transduction and endocytosis

28 September 2017

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Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation

28 September 2017

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Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking

28 September 2017

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c-Kit and c-kit mutations in mastocytosis and other hematological diseases.

28 September 2017

1 reference

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Src family tyrosine kinases and growth factor signaling

28 September 2017

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The biology of stem cell factor and its receptor C-kit

28 September 2017

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Effects of mutant c-Kit in early myeloid cells

28 September 2017

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Signaling via Src family kinases is required for normal internalization of the receptor c-Kit

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Activating mutation in the catalytic domain of c-kit elicits hematopoietic transformation by receptor self-association not at the ligand-induced dimerization site.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Human Peripheral Blood Eosinophils Express a Functional c-kit Receptor for Stem Cell Factor that Stimulates Very Late Antigen 4 (VLA-4)–mediated Cell Adhesion to Fibronectin and Vascular Cell Adhesion Molecule 1 (VCAM-1)

28 September 2017

1 reference

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Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

28 September 2017

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

28 September 2017

1 reference

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Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor

28 September 2017

1 reference

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A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling.

31 May 2018

1 reference

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Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells

31 May 2018

1 reference

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A transforming mutation enhances the activity of the c-Kit soluble tyrosine kinase domain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Control of EGF receptor signaling by clathrin-mediated endocytosis.

31 May 2018

1 reference

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Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Diagnosis, prognosis and treatment of patients with gastrointestinal stromal tumour (GIST) and germline mutation of KIT exon 13.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Gene expression profile of highly purified bone marrow mast cells in systemic mastocytosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Gene expression profile, pathways, and transcriptional system regulation in indolent systemic mastocytosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

The expression of stem cell factor and c-kit receptor in human asthmatic airways

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Signal transduction by several KIT juxtamembrane domain mutations

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3994404

Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

28 November 2018

1 reference

12 December 2020

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

1 reference

12 December 2020

Characterization of c-kit-positive neurons in the dorsal root ganglion of mouse

1 reference

12 December 2020

Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

1 reference

12 December 2020

Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase

1 reference

12 December 2020

c-kit mutation in a population of patients with mastocytosis

1 reference

12 December 2020

1 reference

12 December 2020

Regulation of the EGF transcriptional response by endocytic sorting

1 reference

12 December 2020

Detailed conformational dynamics of juxtamembrane region and activation loop in c-Kit kinase activation process

1 reference

12 December 2020

10.1016/J.IAC.2014.01.002

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

24745671

1 reference