ROCKs as immunomodulators of stroke (Q26853214)

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Language	Label	Description	Also known as
English	ROCKs as immunomodulators of stroke	scientific article

Statements

scholarly article

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ROCKs as immunomodulators of stroke (English)

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author name string

Qing Mei Wang

1

1 reference

James K Liao

2

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language of work or name

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publication date

October 2012

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Expert Opinion on Therapeutic Targets

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16

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10

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1013-25

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Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

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7 April 2017

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

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7 April 2017

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

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7 April 2017

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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7 April 2017

Control of regulatory T cell development by the transcription factor Foxp3

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7 April 2017

Magnetic resonance imaging of human brain macrophage infiltration

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7 April 2017

Transforming growth factor-beta induces development of the T(H)17 lineage

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7 April 2017

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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7 April 2017

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

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7 April 2017

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

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7 April 2017

TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23

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7 April 2017

High glucose-induced upregulation of Rho/Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells

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7 April 2017

Rho GTPases and signaling networks

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7 April 2017

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

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7 April 2017

Heart disease and stroke statistics--2011 update: a report from the American Heart Association

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7 April 2017

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

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7 April 2017

Regulation of the mevalonate pathway

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7 April 2017

Sterile inflammation: sensing and reacting to damage

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7 April 2017

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

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7 April 2017

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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7 April 2017

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

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7 April 2017

Inflammation is detrimental for neurogenesis in adult brain

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7 April 2017

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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7 April 2017

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

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Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

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7 April 2017

Immune mechanisms of stroke.

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28 September 2017

Risk of atrial fibrillation and stroke in rheumatoid arthritis: Danish nationwide cohort study

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28 September 2017

Inhibition of Rho kinases increases directional motility of microvascular endothelial cells

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28 September 2017

von Willebrand factor: an emerging target in stroke therapy.

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28 September 2017

Ischaemic stroke: a thrombo-inflammatory disease?

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28 September 2017

Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses

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28 September 2017

Stroke and the immune system: from pathophysiology to new therapeutic strategies

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28 September 2017

The Rho kinase inhibitor Fasudil up‐regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes

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28 September 2017

Fingolimod provides long-term protection in rodent models of cerebral ischemia

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28 September 2017

Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells

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28 September 2017

Combating innate inflammation: a new paradigm for acute treatment of stroke?

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28 September 2017

Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke

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28 September 2017

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

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28 September 2017

Infectious burden: a new risk factor and treatment target for atherosclerosis

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28 September 2017

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

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28 September 2017

Astrocyte function and role in motor neuron disease: a future therapeutic target?

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28 September 2017

A randomized trial of rosuvastatin in the prevention of venous thromboembolism

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28 September 2017

Increased leukocyte ROCK activity in patients after acute ischemic stroke

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Post-ischemic brain damage: pathophysiology and role of inflammatory mediators.

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Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q

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28 September 2017

Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

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28 September 2017

Immunohistochemical analysis of target proteins of Rho-kinase in a mouse model of accelerated atherosclerosis

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Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice

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ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury

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Acute ischaemic stroke and infection: recent and emerging concepts

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Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms

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28 September 2017

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28 September 2017

Stroke and T-cells

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28 September 2017

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection

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28 September 2017

Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective.

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28 September 2017

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

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28 September 2017

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

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28 September 2017

Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

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28 September 2017

Cerebral neutrophil recruitment, histology, and outcome in acute ischemic stroke: an imaging-based study

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28 September 2017

Targeting eNOS for stroke protection

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28 September 2017

Microglia: neuroprotective and neurotrophic cells in the central nervous system

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28 September 2017

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28 September 2017

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

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28 September 2017

Immune function of microglia

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28 September 2017

Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo

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28 September 2017

Rho kinases play an obligatory role in vertebrate embryonic organogenesis

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28 September 2017

Microglia: activation and their significance in the central nervous system

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28 September 2017

Transcriptional regulation of Th1/Th2 polarization

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28 September 2017

Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization

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28 September 2017

Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats

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28 September 2017

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies

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28 September 2017

Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor

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28 September 2017

Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury

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28 September 2017

Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells

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28 September 2017

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28 September 2017

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons

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28 September 2017

Cell-surface-expressed T-cell antigen-receptor zeta chain is associated with the cytoskeleton

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28 September 2017

Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65.

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31 May 2018

Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury

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31 May 2018

Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system

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31 May 2018

Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

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31 May 2018

Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.

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31 May 2018

Cortical Protection by Localized Striatal Injection of IL-1ra Following Cerebral Ischemia in the Rat

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31 May 2018

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

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31 May 2018

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

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21 January 2018

Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial

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21 January 2018

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Prospective study of markers of hemostatic function with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Deficiency of von Willebrand factor protects mice from ischemic stroke

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Fasudil protects hippocampal neurons against hypoxia‐reoxygenation injury by suppressing microglial inflammatory responses in mice

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Early neutrophilia is associated with volume of ischemic tissue in acute stroke.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Deficiency of intercellular adhesion molecule 1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Mechanism of insulin-like growth factor I-mediated proliferation of adult neural progenitor cells: role of Akt.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

T helper 1 (Th1)/Th2 cytokine expression shift of peripheral blood CD4+ and CD8+ T cells in patients at the post-acute phase of stroke.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Microglia protect neurons against ischemia by synthesis of tumor necrosis factor.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

in Vivo Monitoring of Macrophage Infiltration in Experimental Ischemic Brain Lesions by Magnetic Resonance Imaging

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Relative Value of Inflammatory, Hemostatic, and Rheological Factors for Incident Myocardial Infarction and Stroke

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Rho and Rho-kinase Mediate Thrombin-induced Phosphatidylinositol 4-Phosphate 5-Kinase Trafficking in Platelets

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.715149

21 January 2018

Increased incidence of stroke and impaired prognosis after stroke among patients with seropositive rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807092

28 November 2018

Lipopolysaccharide enhances synthesis of brain-derived neurotrophic factor in cultured rat microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807092

28 November 2018

High-dose atorvastatin after stroke or transient ischemic attack

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow cytometric analysis of inflammatory cells in ischemic rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency, etiology, and prevention of stroke in patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The vascular biology of the glycoprotein Ib-IX-V complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoA and the function of platelet integrin alphaIIbbeta3

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on CD28 signaling and preferential inhibition of IL-10 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22925075

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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