Disordered follicle development (Q26851230)

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Language	Label	Description	Also known as
English	Disordered follicle development	scientific article

Statements

scholarly article

1 reference

Disordered follicle development (English)

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author name string

R. Jeffrey Chang

1

1 reference

Heidi Cook-Andersen

2

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language of work or name

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publication date

5 July 2013

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Molecular and Cellular Endocrinology

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373

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1-2

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51-60

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Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

7 April 2017

Betaglycan binds inhibin and can mediate functional antagonism of activin signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

7 April 2017

Growth differentiation factor-9 is required during early ovarian folliculogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

7 April 2017

Clinical Evidence for Predominance of Delta-5 Steroid Production in Women with Polycystic Ovary Syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Characterization of functionally typical and atypical types of polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Follicle dynamics and anovulation in polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

The serine phosphorylation hypothesis of polycystic ovary syndrome: a unifying mechanism for hyperandrogenemia and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Anti-müllerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

The bone morphogenetic protein system in mammalian reproduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Inhibin is an antagonist of bone morphogenetic protein signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Androgens stimulate early stages of follicular growth in the primate ovary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Hormonal control of gene expression in the ovary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Morphology and morphogenesis of the Stein-Leventhal ovary and of so-called "hyperthecosis".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Enhancement of follicle-stimulating hormone-induced aromatase activity by androgens in cultured rat granulosa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Involvement of estrogens in the regulation of granulosa cell aromatase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Maturation of ovarian follicles: actions and interactions of pituitary and ovarian hormones on follicular cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Adenosine 3',5'-Monophosphate, Luteinizing Hormone Receptor, and Progesterone during Granulosa Cell Differentiation: Effects of Estradiol and Follicle- Stimulating Hormone*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Ovarian Follicular Development in the Rat: Hormone Receptor Regulation by Estradiol, Follicle Stimulating Hormone and Luteinizing Hormone1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 September 2017

Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Regulation of androgen production in cultured human thecal cells by insulin-like growth factor I and insulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Enhanced disparity of gonadotropin secretion by estrone in women with polycystic ovarian disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Evidence that granulosa cell aromatase induction/activation by follicle-stimulating hormone is an androgen receptor-regulated process in-vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

The Effects of Continuous Androgen Secretion on the Hypothalamic-Pituitary Axis in Woman: Evidence from a Luteinized Thecoma of the Ovary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Androgen modulation of follicle-stimulating hormone-induced granulosa cell steroidogenesis in the primate ovary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Androgen inhibition of follicle-stimulating hormone-stimulated luteinizing hormone receptor formation in cultured rat granulosa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Theca function in polycystic ovaries of a patient with virilizing congenital adrenal hyperplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Recovery of hormone secretion after chronic gonadotropin-releasing hormone agonist administration in women with polycystic ovarian disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

The effects of insulin and insulin-like growth factors-I and -II on estradiol production by granulosa cells of polycystic ovaries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Effect of recombinant inhibin on androgen synthesis in cultured human thecal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Stimulation of aromatase activity by follicle stimulating hormone in rat granulosa cells in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

31 May 2018

Müllerian-inhibiting substance inhibits cytochrome P450 aromatase activity in human granulosa lutein cell culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Prolonged survival in culture of preantral follicles from polycystic ovaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Gonadotrophin stimulation of non-luteinized granulosa cells increases steroid production and the expression of enzymes involved in estrogen and progesterone synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Granulosa cell production of anti-Müllerian hormone is increased in polycystic ovaries.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

The effect of androgen blockade on granulosa cell estradiol production after follicle-stimulating hormone stimulation in women with polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Comparison of follicle-stimulating-hormone-stimulated dimeric inhibin and estradiol responses as indicators of granulosa cell function in polycystic ovary syndrome and normal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Anti-Müllerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Enhanced granulosa cell responsiveness to follicle-stimulating hormone during insulin infusion in women with polycystic ovary syndrome treated with pioglitazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Formation and early development of follicles in the polycystic ovary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Serum anti-Müllerian hormone dynamics during controlled ovarian hyperstimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Absent biologically relevant associations between serum inhibin B concentrations and characteristics of polycystic ovary syndrome in normogonadotrophic anovulatory infertility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Luteinizing hormone receptor, steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Bone morphogenetic protein inhibits ovarian androgen production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Androgen and follicle-stimulating hormone interactions in primate ovarian follicle development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Functional integrity of granulosa cells from polycystic ovaries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Insulin stimulates androgen accumulation in incubations of human ovarian stroma and theca.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3727408

28 November 2018

Follicle-Stimulating Hormone-Mediated Induction of Functional Luteinizing Hormone/Human Chorionic Gonadotropin Receptors during Monolayer Culture of Porcine Granulosa Cells*

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibin A, inhibin B and activin A concentrations in follicular fluid from women with polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogens augment the stimulation of ovarian aromatase activity by follicle-stimulating hormone in cultured rat granulosa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement and desensitization of hormone-responsive adenylate cyclase in granulosa cells of preantral and antral ovarian follicles: effects of estradiol and follicle-stimulating hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat Granulosa Cell Differentiation: An in Vitro Model*

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogens Enhance the Adenosine 3′,5′-Monophosphate- Mediated Induction of Follicle-Stimulating Hormone and Luteinizing Hormone Receptors in Rat Granulosa Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: relation to IGF action

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of long term testosterone administration on pulsatile luteinizing hormone secretion and on ovarian histology in eugonadal female to male transsexual subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Androgen receptor expression in human ovarian and uterine tissue of long-term androgen-treated transsexual women

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estradiol production by granulosa cells of normal and polycystic ovaries: relationship to menstrual cycle history and concentrations of gonadotropins and sex steroids in follicular fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic regulation of androgen production by human thecal cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome: relevance to mechanism of anovulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone morphogenetic proteins (BMP) -4, -6, and -7 potently suppress basal and luteinizing hormone-induced androgen production by bovine theca interna cells in primary culture: could ovarian hyperandrogenic dysfunction be caused by a defect in thecal

1 reference

https://pubmed.ncbi.nlm.nih.gov/22874072

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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