A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19 (Q26849476)

language of work or name

1 reference

January 2014

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published in

Immunological Reviews

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volume

257

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1 reference

181-90

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T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

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Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

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The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race

7 April 2017

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Molecular Reconstruction of Sleeping Beauty, a Tc1-like Transposon from Fish, and Its Transposition in Human Cells

7 April 2017

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Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells

7 April 2017

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28 September 2017

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Clinical application of Sleeping Beauty and artificial antigen presenting cells to genetically modify T cells from peripheral and umbilical cord blood

28 September 2017

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28 September 2017

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Sleeping beauty system to redirect T-cell specificity for human applications

28 September 2017

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Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy

28 September 2017

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Bispecific T-cells expressing polyclonal repertoire of endogenous γδ T-cell receptors and introduced CD19-specific chimeric antigen receptor

28 September 2017

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Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis

28 September 2017

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Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64

28 September 2017

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A new approach to simultaneously quantify both TCR α- and β-chain diversity after adoptive immunotherapy

28 September 2017

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A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

28 September 2017

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A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis

28 September 2017

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Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies

28 September 2017

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PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor

28 September 2017

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Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies.

28 September 2017

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The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor

28 September 2017

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Translating Sleeping Beauty transposition into cellular therapies: victories and challenges

28 September 2017

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Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies.

28 September 2017

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K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate

28 September 2017

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piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies

28 September 2017

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A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

28 September 2017

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Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

28 September 2017

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Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity.

28 September 2017

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Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

28 September 2017

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The promise and potential pitfalls of chimeric antigen receptors

28 September 2017

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PET imaging of T cells derived from umbilical cord blood

28 September 2017

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Characterization of intracellular HLA-DR, DM and DO profile in K562 and HL-60 leukemic cells

28 September 2017

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Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Antigen-independent and antigen-dependent methods to numerically expand CD19-specific CD8+ T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer

28 September 2017

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Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Sleeping beauty transposon-mediated gene therapy for prolonged expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Sleeping beauty transposition: biology and applications for molecular therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Gene transfer into genomes of human cells by the sleeping beauty transposon system.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Gene silencing as a threat to the success of gene therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Gene silencing: repeats that count

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Use of the human elongation factor 1 alpha promoter as a versatile and efficient expression system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Integrating DNA vectors for gene therapy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity

31 May 2018

1 reference

Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.

21 January 2018

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CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells.

21 January 2018

1 reference

Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells.

21 January 2018

1 reference

Conspiracy of silence among repeated transgenes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Expression of costimulatory molecules in human leukemias.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4109051

Preparation and characterization of a chimeric CD 19 monoclonal antibody

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24329797

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/24329797

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/IMR.12137

1 reference

1 reference

1 reference

PubMed publication ID

24329797

1 reference