1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma (Q26830485)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25947379%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jingjing Duan

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25947379%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

10 June 2020

language of work or name

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19 June 2015

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7 November 2019

6 November 2020

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20 June 2019

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28 September 2019

7 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25947379%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

6 November 2020

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10 June 2020

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10 June 2020

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15380-15389

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The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases

7 April 2017

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Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

7 April 2017

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Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

7 April 2017

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7 April 2017

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Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins

7 April 2017

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An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme

7 April 2017

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Discovery and occurrence of the fumonisins: a historical perspective

7 April 2017

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The External Aldimine Form of Serine Palmitoyltransferase: STRUCTURAL, KINETIC, AND SPECTROSCOPIC ANALYSIS OF THE WILD-TYPE ENZYME AND HSAN1 MUTANT MIMICS

7 April 2017

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The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis

7 April 2017

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Translational aspects of sphingolipid metabolism

7 April 2017

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Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis

7 April 2017

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Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations

7 April 2017

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L-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation

7 April 2017

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Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

28 September 2017

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Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?

28 September 2017

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Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

28 September 2017

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Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificity

28 September 2017

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Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells.

28 September 2017

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Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells

28 September 2017

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Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells

28 September 2017

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Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

28 September 2017

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In vivo formation of N-acyl-fumonisin B1.

28 September 2017

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Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1.

28 September 2017

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Altered sphingoid base profiles in type 1 compared to type 2 diabetes

28 September 2017

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Inflammation triggers production of dimethylsphingosine from oligodendrocytes.

28 September 2017

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Human genetic disorders of sphingolipid biosynthesis

28 September 2017

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Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer

28 September 2017

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Public health impacts of foodborne mycotoxins

28 September 2017

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Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells.

28 September 2017

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Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2.

28 September 2017

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Mutations at Ser331 in the HSN type I gene SPTLC1 are associated with a distinct syndromic phenotype

28 September 2017

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Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

28 September 2017

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Neural tube defects on the Texas-Mexico border: what we've learned in the 20 years since the Brownsville cluster

28 September 2017

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Sphingolipids and plant defense/disease: the "death" connection and beyond

28 September 2017

1 reference

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Structural, mechanistic and regulatory studies of serine palmitoyltransferase

28 September 2017

1 reference

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Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability

28 September 2017

1 reference

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Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system

28 September 2017

1 reference

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Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.

28 September 2017

1 reference

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Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols

28 September 2017

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Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

28 September 2017

1 reference

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Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer

28 September 2017

1 reference

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A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

28 September 2017

1 reference

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Deoxysphingoid bases as plasma markers in diabetes mellitus

28 September 2017

1 reference

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A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity

28 September 2017

1 reference

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Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids

28 September 2017

1 reference

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Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1

28 September 2017

1 reference

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Characterization of mutant serine palmitoyltransferase 1 in LY-B cells

28 September 2017

1 reference

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Maternal fumonisin exposure as a risk factor for neural tube defects

28 September 2017

1 reference

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Cell death induced by nutritional starvation in mouse macrophage-like RAW264.7 cells.

28 September 2017

1 reference

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Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway

28 September 2017

1 reference

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Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals

28 September 2017

1 reference

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Secondary metabolism: regulation and role in fungal biology

28 September 2017

1 reference

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Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols

28 September 2017

1 reference

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Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505451

Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation

28 September 2017

1 reference

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Sphingolipids as targets for microbial infections

28 September 2017

1 reference

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The clinical potential of sphingolipid-based therapeutics

28 September 2017

1 reference

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Fungal sphingolipids as targets for the development of selective antifungal therapeutics.

28 September 2017

1 reference

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2-Amino-14,16-dimethyloctadecan-3-ol, a new sphingosine analogue toxin in the fungal genus Fusarium

28 September 2017

1 reference

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Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize

28 September 2017

1 reference

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Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action

28 September 2017

1 reference

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The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers.

28 September 2017

1 reference

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Sphingolipids in food and the emerging importance of sphingolipids to nutrition

28 September 2017

1 reference

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Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor

28 September 2017

1 reference

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Dihydroceramide biology. Structure-specific metabolism and intracellular localization

28 September 2017

1 reference

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The Golgi apparatus: insights from lipid biochemistry

28 September 2017

1 reference

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Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505451

Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells

31 May 2018

1 reference

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The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations

31 May 2018

1 reference

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Kinetics and metabolic specificities of Vero cells in bioreactor cultures with serum-free medium

31 May 2018

1 reference

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The marine sphingolipid-derived compound ES 285 triggers an atypical cell death pathway

31 May 2018

1 reference

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BRS1, A C30 BIS-Amino, BIS-Hydroxy Polyunsaturated lipid from an australian calcareous sponge that inhibits protein kinase C

31 May 2018

1 reference

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Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme

31 May 2018

1 reference

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Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

31 May 2018

1 reference

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Plasma alanine and lactate concentrations following glucose ingestion in normal and NIDDM subjects

31 May 2018

1 reference

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Mycotoxins reveal connections between plants and animals in apoptosis and ceramide signaling

31 May 2018

1 reference

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Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols.

21 January 2018

1 reference

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Rhizochalin A, a novel two-headed sphingolipid from the sponge Rhizochalina incrustata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.658823

Variation in the alkaloids among indo-pacific Leucetta sponges

21 January 2018

1 reference

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Analysis of Fusarium avenaceum metabolites produced during wet apple core rot.

21 January 2018

1 reference

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Reconstitution of the pyridoxal 5'-phosphate (PLP) dependent enzyme serine palmitoyltransferase (SPT) with pyridoxal reveals a crucial role for the phosphate during catalysis

21 January 2018

1 reference

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Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.658823

Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells.

21 January 2018

1 reference

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Structure and stereochemistry of a novel bioactive sphingolipid from a Calyx sp

21 January 2018

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Mutations in the SPTLC1 Protein Cause Mitochondrial Structural Abnormalities and Endoplasmic Reticulum Stress in Lymphoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.658823

Biochemistry of the sphingolipides; preparation of sphingolipides from beef brain and spinal cord

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505451

Lowering Plasma 1-Deoxysphingolipids Improves Neuropathy in Diabetic Rats

28 November 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.658823

Rhizochalins C and D from the sponge Rhizochalina incrustata. A rare threo-sphingolipid and a facile method for determination of the carbonyl position in alpha,omega-bifunctionalized ketosphingolipids

21 January 2018

1 reference

12 December 2020

Acute effects of fructose and glucose ingestion with and without caffeine in young and old humans

1 reference

12 December 2020

Golgi staining by two fluorescent ceramide analogues in cultured fibroblasts requires metabolism

1 reference

12 December 2020

Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?

1 reference

12 December 2020

Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies

1 reference

12 December 2020

Phase I dose-escalating study of ES-285 given as a three-hour intravenous infusion every three weeks in patients with advanced malignant solid tumors

1 reference

12 December 2020

Enantiodivergent Biosynthesis of the Dimeric Sphingolipid Oceanapiside from the Marine SpongeOceanapia phillipensis. Determination of Remote Stereochemistry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R115.658823

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1074/JBC.R115.658823

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25947379%20AND%20SRC:MED&resulttype=core&format=json

release_nrll6jfjvba7folwrb6t3fsyxu

10 June 2020

Fatcat ID

0 references

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25947379%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25947379%20AND%20SRC:MED&resulttype=core&format=json