Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function (Q26823047)

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English	Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function	scientific article

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scholarly article

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Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function (English)

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author name string

Hongcheng Liu

1

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Kimberly May

2

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language of work or name

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publication date

2012

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Monoclonal Antibodies

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4

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1

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17-23

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Folding and association of the antibody domain CH3: prolyl isomerization preceeds dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

7 April 2017

Trisulfides in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Identification and localization of unpaired cysteine residues in monoclonal antibodies by fluorescence labeling and mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Structural and functional characterization of disulfide isoforms of the human IgG2 subclass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Human IgG2 antibodies display disulfide-mediated structural isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Characterization of lower molecular weight artifact bands of recombinant monoclonal IgG1 antibodies on non-reducing SDS-PAGE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Beta-elimination and peptide bond hydrolysis: two distinct mechanisms of human IgG1 hinge fragmentation upon storage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

THE ROLE OF DISULFIDE BONDS IN THE COMPLEMENT-FIXING AND PRECIPITATING PROPERTIES OF 7S RABBIT AND SHEEP ANTIBODIES

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

RECONSTITUTION OF 7S MOLECULES FROM L AND H POLYPEPTIDE CHAINS OF ANTIBODIES AND GAMMA-GLOBULINS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Structural studies of immunoglobulin G.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

The covalent structure of an entire gammaG immunoglobulin molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

The disulphide bridges of immunoglobulin kappa-chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Immunoglobulin G: functional sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Functional antibody lacking a variable-region disulfide bridge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Structure and function of immunoglobulin domains. V. Binding, University of immunoglobulin G and fragments to placental membrane preparations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Structure and function of immunoglobulin domains. VII. Studies on the structural requirements of human immunoglobulin G for granulocyte binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Binding site of human IgG subclasses and their domains for Fc receptors of activated murine T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

The Role of the Intrachain Disulfide Bond in the Conformation and Stability of the Constant Fragment of the Immunoglobulin Light Chain1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Three-Dimensional Structure of Immunoglobulins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

The role of the inter-heavy chain disulfide bond in modulating the flexibility of immunoglobulin G antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 September 2017

Increased aggregation propensity of IgG2 subclass over IgG1: role of conformational changes and covalent character in isolated aggregates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Contributions of a disulfide bond to the structure, stability, and dimerization of human IgG1 antibody CH3 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Intrachain disulfide bond in the core hinge region of human IgG4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Human IgG3 is decreased and IgG1, IgG2 and IgG4 are unchanged in molecular size by mild reduction and reoxidation without any major change in effector functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human (IgG4) antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Conformational changes accompanying the dissociation and association of immunoglobulin-G subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Intrachain disulphide bridges in immunoglobulin G heavy chains. The Fc fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Variations in the S-S bridges of immunoglobins G: interchain disulfide bridges of gamma G3 myeloma proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Disulphide bridges of a human immunoglobulin G protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Labile disulfide bonds and free thiol groups in human IgG. I. Assignment to IgG1 and IgG2 subclasses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Reduction of the buried intrachain disulfide bond of the constant fragment of the immunoglobulin light chain: global unfolding under physiological conditions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab' fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Fixation of the first component of complement by immune complexes: effect of reduction and fragmentation of antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Structural requirements in the Fc region of rabbit IgG antibodies necessary to induce cytotoxicity by human lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

The mechanism of activation of the first component of complement by a univalent hapten-IgG antibody complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

31 May 2018

Disulfide connectivity of human immunoglobulin G2 structural isoforms

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Human IgG2 antibody disulfide rearrangement in vivo

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Disulfide scrambling in IgG2 monoclonal antibodies: insights from molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Human IgG2 can form covalent dimers

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Free sulfhydryl measurement as an indicator of antibody stability

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Free sulfhydryl in recombinant monoclonal antibodies

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Characterization of antibody aggregation: role of buried, unpaired cysteines in particle formation

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Localization and quantitation of free sulfhydryl in recombinant monoclonal antibodies by differential labeling with 12C and 13C iodoacetic acid and LC-MS analysis

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Degradation of protein disulphide bonds in dilute alkali

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Understanding base-assisted desulfurization using a variety of disulfide-bridged peptides

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Evidence for trisulfide bonds in a recombinant variant of a human IgG2 monoclonal antibody.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

A natural antibody missing a cysteine in VH: consequences for thermodynamic stability and folding.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Active dimer of Epratuzumab provides insight into the complex nature of an antibody aggregate.

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Elucidation of two major aggregation pathways in an IgG2 antibody

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Heterogeneity of recombinant antibodies: linking structure to function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338938

28 November 2018

Inter Heavy–Light Chain Disulphide Bridge in Immune Globulins

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Disulphide Bridges of Immunoglobin G1 Heavy Chains

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Alteration of the conformation of human IgG subclasses by reduction of the hinge SS bonds

1 reference

https://api.crossref.org/works/10.4161%2FMABS.4.1.18347

21 January 2018

Recovery of native conformation of rabbit immunoglobulin G upon recombination of separately renatured heavy and light chains at near-neutral pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An in vitro system for studying the kinetics of interchain disulfide bond formation in immunoglobulin G

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of alkali on proteins. Disulfides and their products

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of trisulfide modification in antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranking the susceptibility of disulfide bonds in human IgG1 antibodies by reduction, differential alkylation, and LC-MS analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of reduction and alkylation on structure and function of rabbit IgG antibody—I. Effect on ability to activate complement depends on conditions of reduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free thiol groups and labile disulfide bonds in the IgG fraction of human serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serologic aspects of IgG4 antibodies. II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and biodistribution of recombinant and recombinant/chimeric constructs of monoclonal antibody B72.3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel modification to monoclonal antibodies: thioether cross-link of heavy and light chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Four free cysteine residues found in human IgG1 of healthy donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22327427

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/MABS.4.1.18347

1 reference

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Consolidated OpenCitations Corpus – April 2017

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PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

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