Structure modeling of all identified G protein-coupled receptors in the human genome (Q25256886)

6 July 2017

title

Structure modeling of all identified G protein-coupled receptors in the human genome (English)

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G protein-coupled receptor

6 July 2017

main subject

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Jeffrey Skolnick

1 reference

6 July 2017

Yang Zhang

1 reference

6 July 2017

Mark E Devries

series ordinal

1 reference

6 July 2017

language of work or name

English

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publication date

17 February 2006

1 reference

PLOS Computational Biology

6 July 2017

published in

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6 July 2017

1 reference

6 July 2017

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6 July 2017

page(s)

e13

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Creative Commons Attribution 4.0 International

6 July 2017

start time

17 February 2006

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

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7 April 2017

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28 September 2017

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28 September 2017

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Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.

28 September 2017

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Site-directed mutagenesis of CCR2 identified amino acid residues in transmembrane helices 1, 2, and 7 important for MCP-1 binding and biological functions.

28 September 2017

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Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.

28 September 2017

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Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

1 reference

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28 September 2017

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28 September 2017

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SPICKER: a clustering approach to identify near-native protein folds

28 September 2017

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Identification of amino acid residues crucial for chemokine receptor dimerization.

28 September 2017

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Assessment of homology-based predictions in CASP5.

28 September 2017

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Critical assessment of methods of protein structure prediction (CASP)-round V.

28 September 2017

1 reference

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CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach

28 September 2017

1 reference

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TOUCHSTONE II: a new approach to ab initio protein structure prediction

28 September 2017

1 reference

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Constitutive activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket

28 September 2017

1 reference

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Modeling the 3D structure of GPCRs: advances and application to drug discovery

28 September 2017

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Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

28 September 2017

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Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?

28 September 2017

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Prediction of structure and function of G protein-coupled receptors

28 September 2017

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Local energy landscape flattening: parallel hyperbolic Monte Carlo sampling of protein folding.

28 September 2017

1 reference

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Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression

28 September 2017

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28 September 2017

1 reference

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28 September 2017

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Structural determinants of CCR5 recognition and HIV-1 blockade in RANTES.

28 September 2017

1 reference

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Regulation of corticotropin-releasing hormone in vitro

28 September 2017

1 reference

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The seventh transmembrane domain of cc chemokine receptor 5 is critical for MIP-1beta binding and receptor activation: role of MET 287.

28 September 2017

1 reference

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Interleukin 8, neutrophil-activating peptide-2 and GRO-alpha bind to and elicit cell activation via specific and different amino acid residues of CXCR2.

28 September 2017

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Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368.

28 September 2017

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Structural genomics and its importance for gene function analysis.

28 September 2017

1 reference

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Expression and functional characterization of mutant human CXCR4 in insect cells: role of cysteinyl and negatively charged residues in ligand binding

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Modelling G-protein-coupled receptors for drug design

28 September 2017

1 reference

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Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates

28 September 2017

1 reference

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Protein structure prediction by global optimization of a potential energy function.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins

28 September 2017

1 reference

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28 September 2017

1 reference

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28 September 2017

1 reference

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Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1.

28 September 2017

1 reference

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Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry

28 September 2017

1 reference

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The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998.

28 September 2017

1 reference

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The second extracellular loop of CCR5 is the major determinant of ligand specificity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Site-directed mutagenesis of cysteinyl and serine residues of human thromboxane A2 receptor in insect cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Automated method for modeling seven-helix transmembrane receptors from experimental data

28 September 2017

1 reference

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A model recognition approach to the prediction of all-helical membrane protein structure and topology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Locating ligand-binding sites in 7TM receptors by protein engineering.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector coupling

28 September 2017

1 reference

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Accurate reconstruction of all-atom protein representations from side-chain-based low-resolution models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

BUNDLE: a program for building the transmembrane domains of G-protein-coupled receptors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Partial functional mapping of the human interleukin-8 type A receptor. Identification of a major ligand binding domain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

TASSER: an automated method for the prediction of protein tertiary structures in CASP6.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.

28 November 2018

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A scoring function for docking ligands to low-resolution protein structures.

28 November 2018

1 reference

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Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Species selectivity of nonpeptide antagonists of the gonadotropin-releasing hormone receptor is determined by residues in extracellular loops II and III and the amino terminus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Exploring deltorphin II binding to the third extracellular loop of the delta-opioid receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

How Well is Enzyme Function Conserved as a Function of Pairwise Sequence Identity?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Mutagenesis studies of the human MT2 melatonin receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Important amino acids for the function of the human MT1 melatonin receptor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Ligand-selective activation of mu-oid receptor: demonstrated with deletion and single amino acid mutations of third intracellular loop domain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Identification of cysteines involved in ligand binding to the human melatonin MT(2) receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Complete mutagenesis of the extracellular domain of interleukin-8 (IL-8) type A receptor identifies charged residues mediating IL-8 binding and signal transduction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1364505

Coordinated Up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain barrier

28 November 2018

1 reference

12 December 2020

Two Basic Amino Acids in the Second Inner Loop of the Interleukin-8 Receptor Are Essential for Gα16 Coupling

1 reference

12 December 2020

The ligand binding site of the formyl peptide receptor maps in the transmembrane region

1 reference

12 December 2020

Differential mechanisms of recognition and activation of interleukin-8 receptor subtypes

1 reference

12 December 2020

Use of a disulfide cross-linking strategy to study muscarinic receptor structure and mechanisms of activation

1 reference

12 December 2020

1 reference

12 December 2020

Identification of Putative Sites of Interaction between the Human Formyl Peptide Receptor and G Protein

1 reference

12 December 2020

10.1371/JOURNAL.PCBI.0020013

Identifiers

DOI

1 reference

journals/ploscb/ZhangDS06

6 July 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

6 July 2017

1 reference