Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells (Q24794136)

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Elizabeth Yan

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Nicole Salloum

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Matthew Parliament

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Joan Allalunis-Turner

describes a project that uses

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language of work or name

English

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publication date

12 July 2004

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ImageQuant

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC481082/fullTextXML

inferred from PubMed Central ID database lookup

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7 April 2017

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7 April 2017

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The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme

7 April 2017

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Human complex I deficiency: clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect

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Leber's hereditary optic neuropathy in Indonesia: two families with the mtDNA 11778G>A and 14484T>C mutations

7 April 2017

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Leber's hereditary optic neuropathy: clinical and molecular genetic results obtained in a family with a new point mutation at nucleotide position 14498 in the ND 6 gene

7 April 2017

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Normal variants of human mitochondrial DNA and translation products: the building of a reference data base

7 April 2017

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An ND-6 mitochondrial DNA mutation associated with Leber hereditary optic neuropathy

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Genetic and functional analysis of mitochondrial DNA-encoded complex I genes

7 April 2017

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Mitochondria as targets for detection and treatment of cancer.

28 September 2017

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Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age.

28 September 2017

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

28 September 2017

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Variation in mitochondrial function in hypoxia-sensitive and hypoxia-tolerant human glioma cells

28 September 2017

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Cytochrome C oxidase and the regulation of oxidative phosphorylation.

28 September 2017

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Mitochondrial genetic control of assembly and function of complex I in mammalian cells

28 September 2017

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Complex I: a chimaera of a redox and conformation-driven proton pump?

28 September 2017

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High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples

28 September 2017

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The determination of complete human mitochondrial DNA sequences in single cells: implications for the study of somatic mitochondrial DNA point mutations

28 September 2017

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The oxidative phosphorylation (OXPHOS) system: nuclear genes and human genetic diseases

28 September 2017

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Expression and localization of cyclin-dependent kinase 5 in apoptotic human glioma cells

28 September 2017

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Mitochondrial genetics and disease

28 September 2017

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Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism

28 September 2017

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Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Mitochondrial DNA determines the cellular response to cancer therapeutic agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Modulation of oxygen consumption rate and vascular endothelial growth factor mRNA expression in human malignant glioma cells by hypoxia

28 September 2017

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Oxidative phosphorylation at the fin de siècle

28 September 2017

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Somatic mutations of the mitochondrial genome in human colorectal tumours

28 September 2017

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Simultaneous transfer of mitochondrial DNA and single chromosomes in somatic cells: a novel approach for the study of defects in nuclear-mitochondrial communication

28 September 2017

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Anomalous patterns of nitroimidazole binding adjacent to necrosis in human glioma xenografts: possible role of decreased oxygen consumption

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Topology prediction for helical transmembrane proteins at 86% accuracy

28 September 2017

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Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Conservation and prediction of solvent accessibility in protein families

28 September 2017

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Muscarinic receptor subtypes

28 September 2017

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Chemosensitivity testing of small cell lung cancer using the MTT assay.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Electron microscopic analysis of the peripheral and membrane parts of mitochondrial NADH dehydrogenase (Complex I)

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

In vivo labeling and analysis of human mitochondrial translation products

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Mitochondrial genetics and human disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction

30 May 2018

1 reference

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Heterogeneity in response to treatment with buthionine sulfoximine or interferon in human malignant glioma cells

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Flow cytometry in the study of mitochondrial respiratory chain disorders.

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Mitochondrial DNA nucleotide changes C14482G and C14482A in the ND6 gene are pathogenic for Leber's hereditary optic neuropathy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Impact of mutations affecting ND mitochondria-encoded subunits on the activity and assembly of complex I in Chlamydomonas. Implication for the structural organization of the enzyme

28 November 2018

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Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Hypoxia causes downregulation of protein and RNA synthesis in noncontracting Mammalian cardiomyocytes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

28 November 2018

Targeting cancer therapy

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Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=481082

Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis

28 November 2018

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Hydrophilicity of polar amino acid side-chains is markedly reduced by flanking peptide bonds

28 November 2018

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12 December 2020

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

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12 December 2020

Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates

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12 December 2020

Prediction of protein structure

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12 December 2020

Top-down control analysis of ATP turnover, glycolysis and oxidative phosphorylation in rat hepatocytes

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12 December 2020

Use of fibroblast and lymphoblast cultures for detection of respiratory chain defects

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12 December 2020

Inhibition of human ovarian cancer colony formation by adriamycin and its major metabolites

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12 December 2020

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms

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12 December 2020