Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism (Q24681793)

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English	Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism	scientific article

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scholarly article

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title

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism (English)

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main subject

cell biology

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protein ubiquitination

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based on heuristic

inferred from title

author name string

Mu-Shui Dai

series ordinal

1

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Dingding Shi

series ordinal

2

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Yetao Jin

series ordinal

3

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Xiao-Xin Sun

series ordinal

4

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Yanping Zhang

series ordinal

5

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Steven R Grossman

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6

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Hua Lu

series ordinal

7

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language of work or name

English

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publication date

25 August 2006

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published in

Journal of Biological Chemistry

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volume

281

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issue

34

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page(s)

24304-13

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cites work

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

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7 April 2017

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

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7 April 2017

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

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7 April 2017

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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7 April 2017

Involvement of the DNA repair protein hHR23 in p53 degradation

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PubMed Central

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7 April 2017

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

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PubMed Central

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7 April 2017

p53 has a direct apoptogenic role at the mitochondria

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PubMed Central

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7 April 2017

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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PubMed Central

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7 April 2017

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

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PubMed Central

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7 April 2017

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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PubMed Central

reference URL

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7 April 2017

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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PubMed Central

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7 April 2017

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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PubMed Central

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7 April 2017

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

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PubMed Central

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7 April 2017

Mdm2 promotes the rapid degradation of p53

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PubMed Central

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7 April 2017

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

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PubMed Central

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7 April 2017

Surfing the p53 network

1 reference

stated in

PubMed Central

reference URL

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7 April 2017

Regulation of p53 stability by Mdm2

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PubMed Central

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7 April 2017

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

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PubMed Central

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7 April 2017

A dynamic role of HAUSP in the p53-Mdm2 pathway

1 reference

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PubMed Central

reference URL

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7 April 2017

Regulation of HDM2 activity by the ribosomal protein L11

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

The p53-mdm-2 autoregulatory feedback loop

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PubMed Central

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7 April 2017

Does the ribosome translate cancer?

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PubMed Central

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7 April 2017

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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PubMed Central

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7 April 2017

mdm2 expression is induced by wild type p53 activity

1 reference

stated in

PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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7 April 2017

MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

1 reference

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PubMed Central

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28 September 2017

Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783840

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28 September 2017

Small-molecule inhibitors of the p53 suppressor HDM2: have protein-protein interactions come of age as drug targets?

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PubMed Central

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28 September 2017

At the crossroads of growth control; making ribosomal RNA.

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PubMed Central

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28 September 2017

Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface.

1 reference

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PubMed Central

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28 September 2017

Cell cycle regulatory functions of the human oncoprotein MDM2.

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PubMed Central

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28 September 2017

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

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PubMed Central

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28 September 2017

Decision making by p53: life, death and cancer

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PubMed Central

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28 September 2017

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

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PubMed Central

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28 September 2017

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

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PubMed Central

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28 September 2017

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

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PubMed Central

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28 September 2017

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

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PubMed Central

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28 September 2017

Molecular mechanism of the interaction between MDM2 and p53.

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PubMed Central

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28 September 2017

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

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PubMed Central

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28 September 2017

Stress signals utilize multiple pathways to stabilize p53

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28 September 2017

The MDM2 gene amplification database

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28 September 2017

DNA damage induces phosphorylation of the amino terminus of p53

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PubMed Central

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28 September 2017

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

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28 September 2017

Overexpression of the MDM2 oncogene in leukemia and lymphoma

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28 September 2017

MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).

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A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway

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21 January 2018

p19ARF links the tumour suppressor p53 to Ras

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21 January 2018

p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

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What better measure than ribosome synthesis?

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Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas

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Signaling to p53: breaking the MDM2-p53 circuit

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Identifiers

DOI

10.1074/JBC.M602596200

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PMC publication ID

1783840

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PubMed publication ID

16803902

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ResearchGate publication ID

6980611

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