Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylation (Q24680666)

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Language	Label	Description	Also known as
English	Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylation	scientific article

Statements

instance of

scholarly article

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title

Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylation (English)

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author name string

Jorge Alex Pavon

series ordinal

1

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Paul F Fitzpatrick

series ordinal

2

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language of work or name

English

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publication date

12 September 2006

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published in

Biochemistry

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volume

45

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issue

36

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page(s)

11030-7

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cites work

Mechanism of aromatic amino acid hydroxylation

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7 April 2017

Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin

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PubMed Central

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7 April 2017

Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation

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7 April 2017

Structural basis of autoregulation of phenylalanine hydroxylase

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7 April 2017

Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases

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7 April 2017

Mechanism of aromatic hydroxylation by an activated FeIV=O core in tetrahydrobiopterin-dependent hydroxylases

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7 April 2017

Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. Important role of Phe313 in substrate specificity

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7 April 2017

Hydroxylation-induced migration: the NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds

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Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

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7 April 2017

The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

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28 September 2017

The aromatic amino acid hydroxylases.

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28 September 2017

The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase: implications for the catalytic mechanism

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28 September 2017

Expression and Characterization of the Catalytic Domain of Human Phenylalanine Hydroxylase

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28 September 2017

6 Statistical analysis of enzyme kinetic data

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28 September 2017

L-[2,5-H2]phenylalanine, an alternate substrate for rat liver phenylalanine hydroxylase

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28 September 2017

Uncoupled forms of tyrosine hydroxylase unmask kinetic isotope effects on chemical steps

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30 May 2018

The 2‐His‐1‐Carboxylate Facial Triad — An Emerging Structural Motif in Mononuclear Non‐Heme Iron(II) Enzymes

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30 May 2018

Mechanism of "uncoupled" tetrahydropterin oxidation by phenylalanine hydroxylase.

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30 May 2018

Mechanism of phenylalanine regulation of phenylalanine hydroxylase.

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Steady-state kinetic mechanism of rat tyrosine hydroxylase.

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30 May 2018

Intrinsic deuterium isotope effects on benzylic hydroxylation by tyrosine hydroxylase

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28 November 2018

pH variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same.

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PubMed Central

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28 November 2018

Influence of steric bulk and electrostatics on the hydroxylation regiospecificity of tryptophan hydroxylase: characterization of methyltryptophans and azatryptophans as substrates

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12 December 2020

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Development of a protocol for the automated analysis of amino acids in brain tissue samples and microdialysates

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12 December 2020

based on heuristic

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One motif--many different reactions

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16953590

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12 December 2020

based on heuristic

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Reversing the substrate specificities of phenylalanine and tyrosine hydroxylase: aspartate 425 of tyrosine hydroxylase is essential for L-DOPA formation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16953590

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retention of deuterium in p-tyrosine formed enzymatically from p-deuterophenylalanine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16953590

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. Changes in conformation and catalytic properties

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16953590

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the rate-limiting step in the tyrosine hydroxylase reaction: alternate substrates, solvent isotope effects, and transition-state analogues

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16953590

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16953590

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Chimeric Pterin-Dependent Hydroxylases: Contributions of the Regulatory Domains of Tyrosine and Phenylalanine Hydroxylase to Substrate Specificity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16953590

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and characterization of the catalytic core of tryptophan hydroxylase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16953590

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A continuous fluorescence assay for tryptophan hydroxylase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16953590

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/BI0607554

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PMC publication ID

1945167

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PubMed publication ID

16953590

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ResearchGate publication ID

6835771

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