Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats (Q24652668)

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English	Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats	scientific article

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13 January 2020

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats (English)

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13 January 2020

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Patrick R Gentry

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P. Jeffrey Conn

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Craig W. Lindsley

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Jana K Shirey-Rice

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Micah L Breininger

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Thomas M Bridges

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J Phillip Kennedy

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Analisa D Thompson

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Justin U Heiman

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Satyawan B Jadhav

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4 September 2008

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13 January 2020

Journal of Pharmacology and Experimental Therapeutics

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941-953

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13 January 2020

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

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Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

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Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.

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Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

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A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators

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Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

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Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

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Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system

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M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies

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