Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP (Q24643971)

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Language	Label	Description	Also known as
English	Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP	scientific article

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scholarly article

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Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP (English)

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John P. Richard

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John P Richard

5

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4

object named as

John A Gerlt

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author name string

Tina L Amyes

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Bryant M Wood

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Kui Chan

3

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language of work or name

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publication date

6 February 2008

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Journal of the American Chemical Society

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130

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5

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1574-5

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Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate

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7 April 2017

The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase

1 reference

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7 April 2017

Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase

1 reference

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7 April 2017

Anatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog

1 reference

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Catalytic proficiency: the unusual case of OMP decarboxylase

1 reference

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A proficient enzyme

1 reference

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7 April 2017

Carbanions from decarboxylation of orotate analogs: stability and mechanistic implications

1 reference

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27 September 2017

Stability of the 6-carbanion of uracil analogues: mechanistic implications for model reactions of orotidine-5'-monophosphate decarboxylase

1 reference

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27 September 2017

Catalysis by enzyme conformational change as illustrated by orotidine 5′-monophosphate decarboxylase

1 reference

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27 September 2017

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1 reference

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27 September 2017

OMP decarboxylase: an experimental test of electrostatic destabilization of the enzyme-substrate complex.

1 reference

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28 November 2018

Hydrogen isotope tracing in the reaction of orotidine-5'-monophosphate decarboxylase

1 reference

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28 November 2018

Equilibrium of formation of the 6-carbanion of UMP, a potential intermediate in the action of OMP decarboxylase

1 reference

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28 November 2018

Remarkable rate enhancement of orotidine 5'-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization.

1 reference

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28 November 2018

Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation

1 reference

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28 November 2018

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10.1021/JA710384T

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