Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway (Q24646576)

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Andrew M Farrar

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Regina Vontell

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Lila T Worden

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Colin M Stopper

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Russell G Port

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Kelly S Sink

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Jamie G Bunce

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James J Chrobak

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John D Salamone

Adenosine A2A receptors and basal ganglia physiology

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language of work or name

English

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publication date

3 September 2008

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published in

Journal of Neuroscience

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volume

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issue

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page(s)

9037-46

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cites work

1 reference

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Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism

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Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake

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Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior

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27 September 2017

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27 September 2017

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Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum

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Distribution, biochemistry and function of striatal adenosine A2A receptors

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27 September 2017

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Dopaminergic and glutamatergic regulation of effort- and delay-based decision making

27 September 2017

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Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats.

30 May 2018

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The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis

30 May 2018

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30 May 2018

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Functional specialization within medial frontal cortex of the anterior cingulate for evaluating effort-related decisions.

30 May 2018

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Substantia nigra pars reticulata GABA is involved in the regulation of operant lever pressing: pharmacological and microdialysis studies

30 May 2018

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30 May 2018

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Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study

30 May 2018

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Systemic administration of adenosine A(2A) receptor antagonist reverses increased GABA release in the globus pallidus of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study

30 May 2018

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30 May 2018

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Nucleus accumbens dopamine depletions alter relative response allocation in a T-maze cost/benefit task.

30 May 2018

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Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors

30 May 2018

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[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain

30 May 2018

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Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure

30 May 2018

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Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats

30 May 2018

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A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.

28 November 2018

1 reference

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General and outcome-specific forms of Pavlovian-instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental area.

28 November 2018

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Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing

28 November 2018

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Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making.

28 November 2018

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Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort.

28 November 2018

1 reference

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Ratio and time requirements on operant schedules: effort-related effects of nucleus accumbens dopamine depletions.

28 November 2018

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Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus.

28 November 2018

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Dissociation of the role of nucleus accumbens dopamine in responding to reward-predictive cues and waiting for reward

28 November 2018

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Ventral pallidal representation of pavlovian cues and reward: population and rate codes.

28 November 2018

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Prefrontal cortical-ventral striatal interactions involved in affective modulation of attentional performance: implications for corticostriatal circuit function.

28 November 2018

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The adenosine A2A antagonist KF17837 reverses the locomotor suppression and tremulous jaw movements induced by haloperidol in rats: possible relevance to parkinsonism.

28 November 2018

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Influence of CGS 21680, a selective adenosine A(2A) agonist, on the phencyclidine-induced sensorimotor gating deficit and motor behaviour in rats

28 November 2018

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Nucleus accumbens dopamine and work requirements on interval schedules

28 November 2018

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Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors.

28 November 2018

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Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task

28 November 2018

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Interactions between dopamine D1 receptors and gamma-aminobutyric acid mechanisms in substantia nigra pars reticulata of the rat: neurochemical and behavioral studies

28 November 2018

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Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement.

28 November 2018

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D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption

28 November 2018

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Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement

28 November 2018

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Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study

28 November 2018

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The role of accumbens dopamine in lever pressing and response allocation: effects of 6-OHDA injected into core and dorsomedial shell

28 November 2018

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Motor depressant effects mediated by dopamine D2 and adenosine A2A receptors in the nucleus accumbens and the caudate-putamen

28 November 2018

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Dissociations between appetitive and consummatory responses by pharmacological manipulations of reward-relevant brain regions

28 November 2018

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Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat.

28 November 2018

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Excitatory synaptic transmission in neostriatal neurons: regulation by cyclic AMP-dependent mechanisms

28 November 2018

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The role of mesoaccumbens--pallidal circuitry in novelty-induced behavioral activation.

28 November 2018

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D1 and D2 dopamine receptors differentially increase Fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrain

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18768698

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.1525-08.2008

1 reference

1 reference

1 reference

PubMed publication ID

18768698

1 reference