Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase (Q24646472)

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English	Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase	scientific article

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instance of

scholarly article

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title

Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase (English)

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author name string

Kimberlee M Fischer

series ordinal

1

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Christopher T Cottage

series ordinal

2

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Weitao Wu

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3

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Shabana Din

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4

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Natalie A Gude

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5

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Daniele Avitabile

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6

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Pearl Quijada

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7

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Brett L Collins

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8

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Jenna Fransioli

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9

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Mark A Sussman

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10

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language of work or name

English

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publication date

24 November 2009

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published in

Circulation

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volume

120

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issue

21

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page(s)

2077-87

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cites work

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

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Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

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Pim-1 associates with protein complexes necessary for mitosis

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7 April 2017

Bone marrow cells regenerate infarcted myocardium

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Pim kinase-dependent inhibition of c-Myc degradation

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Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan

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Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

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7 April 2017

Adult cardiac stem cells are multipotent and support myocardial regeneration

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PubMed Central

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7 April 2017

Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload

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PubMed Central

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27 September 2017

Increased cardiac myocyte progenitors in failing human hearts

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27 September 2017

Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation

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27 September 2017

Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function

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PubMed Central

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27 September 2017

Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge

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27 September 2017

Evolution of the c-kit-positive cell response to pathological challenge in the myocardium

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27 September 2017

Stem-cell therapy for cardiac disease

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PubMed Central

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27 September 2017

Myocardial regeneration and stem cell repair

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PubMed Central

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27 September 2017

Human embryonic stem cells: preclinical perspectives

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27 September 2017

Formation of large coronary arteries by cardiac progenitor cells

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PubMed Central

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27 September 2017

Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells

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PubMed Central

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27 September 2017

HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia

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PubMed Central

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27 September 2017

Cardiac regeneration by resident stem and progenitor cells in the adult heart.

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PubMed Central

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27 September 2017

Restoration of cardiac function with progenitor cells.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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27 September 2017

T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery.

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PubMed Central

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27 September 2017

Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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27 September 2017

Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure

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PubMed Central

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27 September 2017

Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.

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PubMed Central

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27 September 2017

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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27 September 2017

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

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PubMed Central

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30 May 2018

Pim-1 regulates cardiomyocyte survival downstream of Akt.

1 reference

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PubMed Central

reference URL

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28 November 2018

Stable therapeutic effects of mesenchymal stem cell-based multiple gene delivery for cardiac repair

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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28 November 2018

Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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28 November 2018

The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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28 November 2018

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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28 November 2018

Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787902

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28 November 2018

Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases Pim-1 and Pim-3

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19901187

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-based ex vivo delivery of angiogenic growth factors for cardiac repair

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19901187

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19901187

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19901187

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19901187

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of pim-1 in smooth muscle cell proliferation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19901187

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1161/CIRCULATIONAHA.109.884403

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1379110

OpenCitations bibliographic resource ID

1379110

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1379110

PMC publication ID

2787902

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1379110

PubMed publication ID

19901187

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1379110

 

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