Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis (Q24631468)

object named as

Jay D Horton

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author name string

Luke J Engelking

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Hiroshi Kuriyama

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Robert E Hammer

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Michael S Brown

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Guosheng Liang

Journal of Clinical Investigation

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language of work or name

English

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publication date

April 2004

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published in

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volume

113

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issue

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page(s)

1168-75

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cites work

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

7 April 2017

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Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

7 April 2017

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The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

7 April 2017

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

7 April 2017

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

7 April 2017

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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

7 April 2017

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

7 April 2017

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Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice

7 April 2017

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Membrane topology of human insig-1, a protein regulator of lipid synthesis

7 April 2017

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Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

7 April 2017

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

7 April 2017

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SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

7 April 2017

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Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

7 April 2017

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Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

7 April 2017

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Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

7 April 2017

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

7 April 2017

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Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

7 April 2017

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

27 September 2017

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27 September 2017

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A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice

27 September 2017

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Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

30 May 2018

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

28 November 2018

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28 November 2018

Identifiers

DOI

10.1172/JCI20978

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PubMed publication ID

15085196

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