A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate (Q24628878)

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Language	Label	Description	Also known as
English	A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate	scientific article

Statements

scholarly article

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A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate (English)

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Cytomegalovirus

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author name string

K K Biron

1

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J A Fyfe

2

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S C Stanat

3

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L K Leslie

4

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J B Sorrell

5

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C U Lambe

6

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D M Coen

7

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language of work or name

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publication date

November 1986

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Proceedings of the National Academy of Sciences of the United States of America

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83

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22

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8769-73

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Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine

1 reference

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7 April 2017

9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication

1 reference

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7 April 2017

Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1

1 reference

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Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses

1 reference

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7 April 2017

Effects of deletions on expression of the herpes simplex virus thymidine kinase gene from the intact viral genome: the amino terminus of the enzyme is dispensable for catalytic activity

1 reference

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27 September 2017

Nucleic acid hybridization for measurement of effects of antiviral compounds on human cytomegalovirus DNA replication

1 reference

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Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine

1 reference

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Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities

1 reference

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Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

1 reference

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Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions

1 reference

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Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1

1 reference

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Mechanism of selective inhibition of human cytomegalovirus replication by 1-beta-D-arabinofuranosyl-5-fluorouracil

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Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

1 reference

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Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus

1 reference

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27 September 2017

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

1 reference

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Induction of host DNA synthesis and DNA polymerase by DNA-negative temperature-sensitive mutants of human cytomegalovirus

1 reference

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Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine

1 reference

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Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387013

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Temperature-sensitive mutants of human cytomegalovirus

1 reference

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Mutants of Herpes Simplex Virus Types 1 and 2 that are Resistant to Phosphonoacetic Acid Induce Altered DNA Polymerase Activities in Infected Cells

1 reference

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Stimulation of Cellular Thymidine Kinases by Human Cytomegalovirus

1 reference

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27 September 2017

Thymidine-kinase in cytomegalovirus infected cells

1 reference

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27 September 2017

Generation of genetic diversity in herpes simplex virus: An antimutator phenotype maps to the DNA polymerase locus

1 reference

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30 May 2018

Altered thymidine-thymidylate kinases from strains of herpes simplex virus with modified drug sensitivities to acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine

1 reference

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Activation by thymidine kinase and potent antiherpetic activity of 2′-nor-2′-deoxyguanosine (2′NDG)

1 reference

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30 May 2018

Treatment of cytomegalovirus retinitis with 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine

1 reference

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30 May 2018

Activity of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine in the treatment of cytomegalovirus pneumonia

1 reference

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Signals for site-specific cleavage of HSV DNA: maturation involves two separate cleavage events at sites distal to the recognition sequences

1 reference

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Cytopathogenic agent resembling human salivary gland virus recovered from tissue cultures of human adenoids.

1 reference

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Enhancement of deoxyguanosine kinase activity in human lung fibroblast cells infected with human cytomegalovirus

1 reference

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The isolation and properties of a variant of Herpes simplex producing multinucleated giant cells in monolayer cultures in the presence of antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/3022304

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based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/3022304

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

9-(1,3-Dihydroxy-2-propoxymethyl)guanine for cytomegalovirus infections in patients with the acquired immunodeficiency syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/3022304

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of 9-(1,3-dihydroxy-2-propoxymethyl)guanine with cytosol and mitochondrial deoxyguanosine kinases: possible role in anti-cytomegalovirus activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3022304

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based on heuristic

inferred from PubMed ID database lookup

MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY

1 reference

https://pubmed.ncbi.nlm.nih.gov/3022304

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.83.22.8769

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1986PNAS...83.8769B

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