Epigenetic alterations in aging (Q24625376)

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Language	Label	Description	Also known as
English	Epigenetic alterations in aging	scientific article

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scholarly article

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Europe PubMed Central

Epigenetic alterations in aging (English)

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author name string

Susana Gonzalo

1

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language of work or name

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publication date

August 2010

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Journal of Applied Physiology

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109

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2

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586-97

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An operational definition of epigenetics

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MicroRNAs: target recognition and regulatory functions

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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

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Most mammalian mRNAs are conserved targets of microRNAs

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Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

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MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

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A microRNA signature of hypoxia

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Lamin A-dependent nuclear defects in human aging

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Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

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The cell nucleus and aging: tantalizing clues and hopeful promises

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

1 reference

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

1 reference

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

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Negative control of p53 by Sir2alpha promotes cell survival under stress

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Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

1 reference

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Structure and ligand of a histone acetyltransferase bromodomain

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

1 reference

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DNA methylation patterns and epigenetic memory

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Translating the Histone Code

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The Sequence of the Human Genome

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Crystal structure of the nucleosome core particle at 2.8 Å resolution

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Structure and function of a human TAFII250 double bromodomain module

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Chromatin modifications and their function

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c-Myc-regulated microRNAs modulate E2F1 expression

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MicroRNA expression profiles classify human cancers

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MicroRNAs: small RNAs with a big role in gene regulation

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The language of covalent histone modifications

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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Histone demethylation by a family of JmjC domain-containing proteins

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Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes.

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Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

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The complex language of chromatin regulation during transcription

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Histone acetylation in chromatin structure and transcription

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CpG-rich islands and the function of DNA methylation

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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MicroRNA regulation of DNA repair gene expression in hypoxic stress

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The epigenomics of cancer

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

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Genomic DNA methylation: the mark and its mediators

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A developmental timing microRNA and its target regulate life span in C. elegans

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Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins

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Genomic instability in laminopathy-based premature aging

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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The nucleosome: from genomic organization to genomic regulation

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

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Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

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Roles of histone acetyltransferases and deacetylases in gene regulation

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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

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Ageing-related chromatin defects through loss of the NURD complex

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Developmentally regulated piRNA clusters implicate MILI in transposon control

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Epigenetics in cancer

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Active genes are tri-methylated at K4 of histone H3

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Epigenetics in cancer

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The mammalian epigenome

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Heterochromatin revisited

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Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression

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The diverse functions of histone lysine methylation

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Histone methylation in transcriptional control

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Alteration of nucleosome structure as a mechanism of transcriptional regulation

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Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage.

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MicroRNAs and cancer epigenetics: a macrorevolution

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Loss of A-type lamins and genomic instability

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Epigenetic Control of MicroRNA Expression and Aging

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The role of epigenetics in aging and age-related diseases

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Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

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Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence

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The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

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How epigenetics can explain human metastasis: a new role for microRNAs

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Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

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Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.

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27 September 2017

microRNAs join the p53 network--another piece in the tumour-suppression puzzle

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DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons

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Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

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The role of nuclear architecture in genomic instability and ageing

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Epigenetics and aging: the targets and the marks

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The epigenetic regulation of mammalian telomeres

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Chromatin challenges during DNA replication and repair

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Epigenetic activation of tumor suppressor microRNAs in human cancer cells

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

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Chromatin remodelling: the industrial revolution of DNA around histones

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The emerging science of epigenomics

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Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

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The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding

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Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger

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The key to development: interpreting the histone code?

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Revealing the world of RNA interference

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Histone lysine methylation: a signature for chromatin function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

An epigenetic road map for histone lysine methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Lamin a truncation in Hutchinson-Gilford progeria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

The many faces of histone lysine methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Unravelling heterochromatin: competition between positive and negative factors regulates accessibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

DNA hypomethylation leads to elevated mutation rates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

DNA methylation and genetic instability in colorectal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

27 September 2017

Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

30 May 2018

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

30 May 2018

The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

30 May 2018

Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Role of Rb family in the epigenetic definition of chromatin.

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Murine microRNAs implicated in liver functions and aging process.

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia.

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Increased expression of histone deacetylase 2 is found in human gastric cancer.

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Infrequent occurrence of age-dependent changes in CpG island methylation as detected by restriction landmark genome scanning

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8.

1 reference

https://api.crossref.org/works/10.1152%2FJAPPLPHYSIOL.00238.2010

21 January 2018

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

28 November 2018

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928596

28 November 2018

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methylation decreases in aging but not in immortal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of chromosomal proteins and DNA of rat brain and its modulation by estradiol and calcium during aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of reiterated sequences in mammalian DNAs Effects of the tissue type, age, malignancy and hormonal induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging and DNA methylation in colorectal mucosa and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20448029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/JAPPLPHYSIOL.00238.2010

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

0 references

PubMed publication ID

0 references

ResearchGate publication ID

0 references

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