Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation (Q24599290)

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English	Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation	scientific article

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scholarly article

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Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation (English)

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author name string

Scott P Runyon

1

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Philip D Mosier

2

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Bryan L Roth

3

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Richard A Glennon

4

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Richard B Westkaemper

5

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language of work or name

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publication date

13 November 2008

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Journal of Medicinal Chemistry

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51

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21

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6808-28

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Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

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24 March 2017

Multiple sequence alignment with the Clustal series of programs

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24 March 2017

Amino acid substitution matrices from protein blocks

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24 March 2017

ALSCRIPT: a tool to format multiple sequence alignments

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24 March 2017

Comparative protein modelling by satisfaction of spatial restraints

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24 March 2017

Modeller: generation and refinement of homology-based protein structure models

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24 March 2017

Application of ligand SAR, receptor modeling and receptor mutagenesis to the discovery and development of a new class of 5-HT(2A) ligands

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24 March 2017

1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists

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24 March 2017

Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology

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24 March 2017

9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist

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24 March 2017

Development and validation of a genetic algorithm for flexible docking

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24 March 2017

A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors

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24 March 2017

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

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7 April 2017

Modeling activated states of GPCRs: the rhodopsin template

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27 September 2017

Differential phospholipase C activation by phenylalkylamine serotonin 5-HT 2A receptor agonists

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27 September 2017

Model structures of alpha-2 adrenoceptors in complex with automatically docked antagonist ligands raise the possibility of interactions dissimilar from agonist ligands

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27 September 2017

The ring of the rhodopsin chromophore in a hydrophobic activation switch within the binding pocket.

1 reference

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27 September 2017

Coupling of retinal isomerization to the activation of rhodopsin

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27 September 2017

Conformational changes of G protein-coupled receptors during their activation by agonist binding

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Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

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Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists

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Molecular biology of serotonin receptors structure and function at the molecular level

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27 September 2017

Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene

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27 September 2017

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

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27 September 2017

Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene

1 reference

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27 September 2017

Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

27 September 2017

Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5.

1 reference

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27 September 2017

Mutational analysis of the antagonist-binding site of the histamine H(1) receptor

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27 September 2017

Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation

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27 September 2017

Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor.

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Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints

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27 September 2017

Mapping of dopamine D3 receptor binding site by pharmacological characterization of mutants expressed in CHO cells with the Semliki Forest virus system

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27 September 2017

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

27 September 2017

The probable arrangement of the helices in G protein-coupled receptors.

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27 September 2017

Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines

1 reference

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27 September 2017

A single point mutation increases the affinity of serotonin 5-HT1D alpha, 5-HT1D beta, 5-HT1E and 5-HT1F receptors for beta-adrenergic antagonists

1 reference

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27 September 2017

Multiple serotonin receptors: clinical and experimental aspects

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Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane

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27 September 2017

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists

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Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors

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27 September 2017

Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

27 September 2017

Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

27 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

27 September 2017

The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine.

1 reference

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27 September 2017

5-Hydroxytryptamine2A (5-HT2A) receptor desensitization can occur without down-regulation

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27 September 2017

Site-directed mutagenesis of Tyr417 in the rat D2 dopamine receptor

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30 May 2018

A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.

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30 May 2018

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30 May 2018

Mutations of transmembrane IV and V serines indicate that all tryptamines do not bind to the rat 5-HT2A receptor in the same manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

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30 May 2018

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber

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30 May 2018

Chimeras of alpha1-adrenergic receptor subtypes identify critical residues that modulate active state isomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

30 May 2018

A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors.

1 reference

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30 May 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

30 May 2018

Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand-binding specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

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1 reference

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30 May 2018

A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

30 May 2018

Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

30 May 2018

Multistructure 3D-QSAR Studies on a Series of Conformationally Constrained Butyrophenones Docked into a New Homology Model of the 5-HT2AReceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

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Molecular dynamics simulation of the human adenosine A3 receptor: agonist induced conformational changes of Trp243.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta1-adrenergic receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

Conformational diversity of ligands bound to proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

Conformational energy penalties of protein-bound ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

Site-directed mutagenesis of the human 5-HT1B receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

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1 reference

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Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3088499

28 November 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conform

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational changes of small molecules binding to proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of the interaction between aryloxypropanolamines and Asn386 in helix VII of the human 5-hydroxytryptamine1A receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin receptor affinities of psychoactive phenalkylamine analogues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of interaction between agonists and asn293 in helix VI of human beta(2)-adrenergic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments

1 reference

https://pubmed.ncbi.nlm.nih.gov/18847250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palladium-catalyzed inter- and intramolecular cross-coupling reactions of B-alkyl-9-borabicyclo[3.3.1]nonane derivatives with 1-halo-1-alkenes or haloarenes. Syntheses of functionalized alkenes, arenes, and cycloalkenes via a hydroboration-coupling

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1021/JA00183A048

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10.1021/JM800771X

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