Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages (Q24561388)

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scientific article published on December 1, 1997

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English	Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages	scientific article published on December 1, 1997

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scholarly article

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Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages (English)

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author name string

K. Pahan

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9389730

27 November 2024

F. G. Sheikh

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9389730

27 November 2024

A. M. Namboodiri

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9389730

27 November 2024

I. Singh

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9389730

27 November 2024

language of work or name

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publication date

1 December 1997

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full work available at URL

http://www.jci.org/articles/view/119812/files/pdf

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9389730

27 November 2024

https://europepmc.org/articles/PMC508470

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9389730

27 November 2024

https://europepmc.org/articles/PMC508470?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9389730

27 November 2024

http://www.jci.org/articles/view/119812/files/pdf

1 reference

10.1172/JCI119812

https://api.crossref.org/works/10.1172/JCI119812

27 November 2024

Journal of Clinical Investigation

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100

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11

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2671-9

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Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes

1 reference

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

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24 March 2017

Regulation of the mevalonate pathway

1 reference

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7 April 2017

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Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

1 reference

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7 April 2017

Nitric oxide as a secretory product of mammalian cells

1 reference

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7 April 2017

Nitric oxide: a neural messenger

1 reference

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Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

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27 September 2017

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex

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In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases

1 reference

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Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2.

1 reference

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Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase

1 reference

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p21ras is modified by a farnesyl isoprenoid

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Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

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DNA deaminating ability and genotoxicity of nitric oxide and its progenitors

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27 September 2017

Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions

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27 September 2017

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1 reference

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27 September 2017

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

1 reference

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27 September 2017

The post-translational modification of ras p21 is important for Raf-1 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Induction of nitric oxide synthase in rat C6 glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Effect of an intermittent treatment and influence of obesity

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Characterization of ameboid microglia isolated from developing mammalian brain.

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Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability

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Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis

1 reference

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Phenylacetate: a novel nontoxic inducer of tumor cell differentiation

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Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes

1 reference

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Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells.

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Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors.

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Human astrocyte production of tumour necrosis factor-alpha, interleukin-1 beta, and interleukin-6 following exposure to lipopolysaccharide endotoxin

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Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide

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Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn

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N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes

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10.1172/JCI119812

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