G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels (Q24537396)

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L T Izu

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H Cheng

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M Kuschel

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H Spurgeon

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E G Lakatta

cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits

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language of work or name

English

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publication date

November 2000

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2547-56

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cites work

1 reference

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Localization of protein kinases by anchoring proteins: a theme in signal transduction

24 March 2017

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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

24 March 2017

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G proteins: transducers of receptor-generated signals

24 March 2017

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Calcium signal transduction from caveolae

7 April 2017

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Primary structure and function of an A kinase anchoring protein associated with calcium channels

27 September 2017

1 reference

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Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases

27 September 2017

1 reference

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

27 September 2017

1 reference

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cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists

27 September 2017

1 reference

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Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

27 September 2017

1 reference

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Neural regulation of the heart beat

27 September 2017

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Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels

27 September 2017

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A G protein directly regulates mammalian cardiac calcium channels

27 September 2017

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Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes

27 September 2017

1 reference

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Direct regulation of cardiac Ca2+ channels by G proteins: neither proven nor necessary?

27 September 2017

1 reference

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Comparison of beta adrenergic receptor subtypes in mammalian tissues

27 September 2017

1 reference

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Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor

27 September 2017

1 reference

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Compartmentation of cyclic adenosine 3',5'-monophosphate signaling in caveolae

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301137

Beta-2 adrenergic activation of L-type Ca++ current in cardiac myocytes

30 May 2018

1 reference

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Dissection of protein kinase and phosphatase targeting interactions

30 May 2018

1 reference

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Compartmentalized structure of the plasma membrane for receptor movements as revealed by a nanometer-level motion analysis

30 May 2018

1 reference

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M2-specific muscarinic cholinergic receptor-mediated inhibition of cardiac regulatory protein phosphorylation

30 May 2018

1 reference

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Multiple kinetic effects of beta-adrenergic stimulation on single cardiac L-type Ca channels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1301137

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

30 May 2018

1 reference

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Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

30 May 2018

1 reference

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A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins

30 May 2018

1 reference

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Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

30 May 2018

1 reference

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Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation

30 May 2018

1 reference

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Effects of beta2-adrenergic stimulation on single-channel gating of rat cardiac L-type Ca2+ channels.

30 May 2018

1 reference

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Pharmacological characterization of the receptors involved in the β‐adrenoceptor‐mediated stimulation of the L‐type Ca2+ current in frog ventricular myocytes

29 November 2018

1 reference

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Beta 2-adrenergic receptor actions in neonatal and adult rat ventricular myocytes

29 November 2018

1 reference

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Response of Failing Canine and Human Heart Cells to β 2 -Adrenergic Stimulation

29 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2800%2976495-2

Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2800%2976495-2

beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3495%2800%2976495-2

G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3495%2800%2976495-2

Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3495%2800%2976495-2

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-3495%2800%2976495-2

A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin

7 January 2021

1 reference

12 December 2020

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist

1 reference

12 December 2020

Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation

1 reference

12 December 2020

Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes

1 reference

12 December 2020

Multiple mechanisms of receptor-G protein signaling specificity

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12 December 2020

Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling

1 reference

12 December 2020

Beta-adrenergic receptor subtypes and subcellular compartmentation of cyclic AMP and cyclic AMP-dependent protein kinase in rabbit cardiomyocytes

1 reference

12 December 2020

10.1016/S0006-3495(00)76495-2

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

11053129

1 reference