A computational study of off-target effects of RNA interference (Q24521012)

2 July 2017

title

A computational study of off-target effects of RNA interference (English)

1 reference

2 July 2017

1 reference

Coen M Adema

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2 July 2017

Shibin Qiu

1 reference

2 July 2017

Terran Lane

series ordinal

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2 July 2017

language of work or name

English

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publication date

30 March 2005

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2 July 2017

published in

Nucleic Acids Research

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2 July 2017

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2 July 2017

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2 July 2017

page(s)

1834-1847

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MicroRNA targets in Drosophila

2 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

RNA interference: biology, mechanism, and applications

24 March 2017

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Computational identification of Drosophila microRNA genes

24 March 2017

1 reference

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Basic local alignment search tool

24 March 2017

1 reference

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Prediction of mammalian microRNA targets

24 March 2017

1 reference

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Functional siRNAs and miRNAs Exhibit Strand Bias

24 March 2017

1 reference

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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

24 March 2017

1 reference

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

24 March 2017

1 reference

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

7 April 2017

1 reference

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Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

24 March 2017

1 reference

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24 March 2017

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Killing the messenger: short RNAs that silence gene expression

24 March 2017

1 reference

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Vertebrate microRNA genes

24 March 2017

1 reference

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

24 March 2017

1 reference

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Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

24 March 2017

1 reference

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Rational siRNA design for RNA interference

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Expression profiling reveals off-target gene regulation by RNAi

7 April 2017

1 reference

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Analysis of gene function in somatic mammalian cells using small interfering RNAs

7 April 2017

1 reference

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Development of gene-specific double-stranded RNA drugs

7 April 2017

1 reference

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A probabilistic model of 3' end formation in Caenorhabditis elegans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

RNA interference in protozoan parasites

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Effects on RNAi of the tight structure, sequence and position of the targeted region.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

A rapid method for detection of putative RNAi target genes in genomic data

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

The specifics of small interfering RNA specificity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Specificity of short interfering RNA determined through gene expression signatures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Genomewide view of gene silencing by small interfering RNAs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Blocking oncogenes in malignant cells by RNA interference--new hope for a highly specific cancer treatment?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Modulation of HIV-1 replication by RNA interference

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

RNA interference in Trypanosoma brucei: cloning of small interfering RNAs provides evidence for retroposon-derived 24-26-nucleotide RNAs.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Targeted mRNA degradation by double-stranded RNA in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Hopes rise for RNA therapy as mouse study hits target

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

A comparison of siRNA efficacy predictors.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Improved and automated prediction of effective siRNA.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

An algorithm for selection of functional siRNA sequences.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Mismatch string kernels for discriminative protein classification

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1072799

Gene silencing in worms and fungi

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15800213

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKI324

1 reference

release_5z3yjbvzsrglfon37xjh5sorvu

2 July 2017

Fatcat ID

0 references

OpenCitations bibliographic resource ID

2494109

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2494109

1 reference