The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes (Q24529077)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899845%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes (English)

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11 January 2020

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0 references

1 reference

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11 January 2020

Emiko Kondo

1 reference

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11 January 2020

Zhaodi Gu

series ordinal

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11 January 2020

Shinichi Fukushige

series ordinal

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11 January 2020

language of work or name

English

0 references

publication date

1 June 2005

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Molecular and Cellular Biology

11 January 2020

published in

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11 January 2020

volume

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11 January 2020

issue

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11 January 2020

page(s)

4388-4396

1 reference

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The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity

11 January 2020

cites work

1 reference

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Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin

24 March 2017

1 reference

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The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Identification and characterization of a family of mammalian methyl-CpG binding proteins

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3

24 March 2017

1 reference

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

24 March 2017

1 reference

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Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair

24 March 2017

1 reference

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MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Methyl-CpG-binding proteins. Targeting specific gene repression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells

27 September 2017

1 reference

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A systematic profile of DNA methylation in human cancer cell lines

27 September 2017

1 reference

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Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140624

Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15899845

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.25.11.4388-4396.2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899845%20AND%20SRC:MED&resulttype=core&format=json

release_l3vx3zghbzexnerbnjpo5h7jkm

11 January 2020

Fatcat ID

0 references

OpenCitations bibliographic resource ID

4192558

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4192558

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899845%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

15899845

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15899845%20AND%20SRC:MED&resulttype=core&format=json