Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair (Q24336157)

positive regulation of Ras protein signal transduction

GOA release 2020-03-11

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GOA release 2020-03-11

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Elia Di Schiavi

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Avi Ma'ayan

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Martin Zenker

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Anna Lipzen

object named as

Anna Lipzen

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Len A. Pennacchio

object named as

Len A Pennacchio

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Valentina Fodale

object named as

Valentina Fodale

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author name string

Alessio Cardinale

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Joel Martin

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Maria C Digilio

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Simone Martinelli

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Deborah Bartholdi

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Giovanni B Ferrero

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Cecilia Anichini

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Angelo Selicorni

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Cesare Rossi

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Romano Tenconi

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Daniela Merlo

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Ravi Iyengar

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Paolo Bazzicalupo

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Bruce D Gelb

MINT: the Molecular INTeraction database

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language of work or name

English

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publication date

September 2009

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1022-6

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

The cardiofaciocutaneous syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Formation of regulatory patterns during signal propagation in a Mammalian cellular network

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences

19 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

The biology and enzymology of protein N-myristoylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Multiple lentigines syndrome. Case report and review of the literature

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

A note on two problems in connexion with graphs

19 March 2017

1 reference

https://api.crossref.org/works/10.1038/NG.425

Multiple lentigines syndrome

22 April 2017

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https://api.crossref.org/works/10.1038/NG.425

Hyperactive Ras in developmental disorders and cancer

22 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

IntAct--open source resource for molecular interaction data

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

BIND: the Biomolecular Interaction Network Database

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Genes2Networks: connecting lists of gene symbols using mammalian protein interactions databases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Trafficking and signaling by fatty-acylated and prenylated proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

PDZBase: a protein-protein interaction database for PDZ-domains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

DIP: The Database of Interacting Proteins: 2001 update

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Loose anagen hair in a child with Noonan's syndrome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765465

Noonan-like syndrome with loose anagen hair: a new syndrome?

30 May 2018

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

21 January 2018

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ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegans

21 January 2018

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Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

21 January 2018

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Amino acid residue penultimate to the amino-terminal gly residue strongly affects two cotranslational protein modifications, N-myristoylation and N-acetylation

21 January 2018

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https://pubmed.ncbi.nlm.nih.gov/19684605

21 January 2018

1 reference

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

GTPase and adenylate cyclase desensitize at different rates in NG108-15 cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19684605

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical and molecular studies in a large Dutch family with Noonan syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19684605

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.425

1 reference

Dimensions Publication ID

1036833666

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1 reference

1 reference

PubMed publication ID

19684605

1 reference