Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2 (Q24322073)

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English	Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2	scientific article

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scholarly article

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Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2 (English)

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SMAD family member 1

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GOA release 2020-03-11

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GOA release 2020-03-11

Bone morphogenetic protein 2

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GOA release 2020-03-11

positive regulation of transcription by RNA polymerase II

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GOA release 2020-03-11

author name string

Xiaoping Yang

1

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Xianzhong Meng

2

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Xin Su

3

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David C Mauchley

4

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Lihua Ao

5

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Joseph C Cleveland

6

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David A Fullerton

7

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language of work or name

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publication date

October 2009

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The Journal of Thoracic and Cardiovascular Surgery

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138

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4

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1008-15

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Establishment and characterization of a stable cell line to evaluate cellular Runx2 activity

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

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based on heuristic

inferred from DOI database lookup

Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2.

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

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based on heuristic

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Calcification and cellularity in human aortic heart valve tissue determine the differentiation of bone-marrow-derived cells.

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Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

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Calcific aortic stenosis: an update

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

7 January 2021

based on heuristic

inferred from DOI database lookup

Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

7 January 2021

based on heuristic

inferred from DOI database lookup

Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

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based on heuristic

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BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways.

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

7 January 2021

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Bone morphogenetic proteins

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

7 January 2021

based on heuristic

inferred from DOI database lookup

Aortic valve calcification: basic science to clinical practice

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

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based on heuristic

inferred from DOI database lookup

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis

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Molecular mechanisms of vascular calcification: lessons learned from the aorta

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based on heuristic

inferred from DOI database lookup

Bone formation and inflammation in cardiac valves

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

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based on heuristic

inferred from DOI database lookup

Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician?

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https://api.crossref.org/works/10.1016%2FJ.JTCVS.2009.06.024

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based on heuristic

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The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1016/J.JTCVS.2009.06.024

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