T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation (Q24321347)

19 October 2023

Balbino Alarcón

Balbino

Alarcón

1 reference

19 October 2023

Ruth M Risueño

Ruth M

Risueño

1 reference

18320063

Creative Commons Attribution 4.0 International

19 October 2023

language of work or name

English

0 references

publication date

2008

0 references

0 references

0 references

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e1747

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start time

5 March 2008

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

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Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

19 March 2017

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Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model

19 March 2017

1 reference

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The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes

19 March 2017

1 reference

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Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

19 March 2017

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Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

19 March 2017

1 reference

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Protein tyrosine kinase structure and function

19 March 2017

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Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif

19 March 2017

1 reference

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How TCRs bind MHCs, peptides, and coreceptors

19 March 2017

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Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

7 April 2017

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A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection

7 April 2017

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Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions

27 September 2017

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The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer

27 September 2017

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Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses

27 September 2017

1 reference

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T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

27 September 2017

1 reference

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Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

27 September 2017

1 reference

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The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits

27 September 2017

1 reference

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Initiation of TCR signaling: regulation within CD3 dimers

27 September 2017

1 reference

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An evolutionary and structural perspective on T cell antigen receptor function

27 September 2017

1 reference

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Structural and thermodynamic correlates of T cell signaling

27 September 2017

1 reference

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The T-cell receptor signalosome: a dynamic structure with expanding complexity

27 September 2017

1 reference

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Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein

27 September 2017

1 reference

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A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

27 September 2017

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The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

The role of T-cell receptor dimerization in T-cell activation.

27 September 2017

1 reference

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Receptor signaling: when dimerization is not enough

27 September 2017

1 reference

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T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

27 September 2017

1 reference

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Ligands for the T-cell receptor: hard times for avidity models

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein.

27 September 2017

1 reference

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The structure and ligand interactions of CD2: implications for T-cell function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

G-protein-coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G-protein recognition

27 September 2017

1 reference

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Making the T cell receptor go the distance: a topological view of T cell activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems

27 September 2017

1 reference

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Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

Ligand binding-dependent limited proteolysis of the atrial natriuretic peptide receptor: juxtamembrane hinge structure essential for transmembrane signal transduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

Switching signals on or off by receptor dimerization

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001747

Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001747

T cell receptor signalling

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254190

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

29 November 2018

1 reference

12 December 2020

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

1 reference

12 December 2020

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2

1 reference

12 December 2020

CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement

1 reference

12 December 2020

A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex

1 reference

12 December 2020

Conformational effect of phosphorylation on T cell receptor/CD3 zeta-chain sequences

1 reference

12 December 2020

Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex

1 reference

12 December 2020

Erythropoietin receptor activation by a ligand-induced conformation change

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0001747

Identifiers

DOI

0 references

ADS bibcode

2008PLoSO...3.1747R

0 references

Fatcat ID

release_c4umbdzbfner7kvrmeadylvr3q

0 references

PMC publication ID

2254190

0 references