A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1 (Q24324095)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

title

A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json

Pro-apoptotic WT1 regulator

21 October 2019

main subject

1 reference

transcription corepressor activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

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21 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

J D Licht

1 reference

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21 October 2019

R H See

1 reference

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21 October 2019

S F Sells

1 reference

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21 October 2019

J Wang

1 reference

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21 October 2019

S Muthukkumar

1 reference

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21 October 2019

D A Haber

1 reference

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21 October 2019

S P Sugrue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

T Roberts

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

V M Rangnekar

1 reference

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21 October 2019

Y Shi

1 reference

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21 October 2019

language of work or name

English

0 references

publication date

1 December 1996

1 reference

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Molecular and Cellular Biology

21 October 2019

published in

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21 October 2019

volume

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21 October 2019

issue

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21 October 2019

page(s)

6945-6956

1 reference

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Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

21 October 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors

19 March 2017

1 reference

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Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

A novel genetic system to detect protein-protein interactions

19 March 2017

1 reference

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WT-1 is required for early kidney development

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

WT1: a novel tumor suppressor gene inactivated in Wilms' tumor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Physical and functional interaction between WT1 and p53 proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Eukaryotic transcriptional regulatory proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The WT1 Wilms' tumor suppressor gene: how much do we really know?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Truncated WT1 mutants alter the subnuclear localization of the wild-type protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The role of WT1 in Wilms tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Nuclear localization of p85s6k: functional requirement for entry into S phase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Interaction between transcription factors Sp1 and YY1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The zinc finger transcription factor EGR-1 impedes interleukin-1-inducible tumor growth arrest

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA-binding proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Antagonism of WT1 activity by protein self-association.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The candidate Wilms' tumour gene is involved in genitourinary development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Alternative splicing and genomic structure of the Wilms tumor gene WT1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Expression of the Wilms' tumor gene WT1 in the murine urogenital system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The genetics of Wilms' tumor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Loss of heterozygosity mapping in Wilms tumor indicates the involvement of three distinct regions and a limited role for nondisjunction or mitotic recombination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The tumor suppressor gene WT1 inhibits ras-mediated transformation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Mutations of the p53 tumor suppressor gene occur infrequently in Wilms' tumor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, wt1, have altered DNA binding specificity and regulate transcription in different ways.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Transcriptional repression mediated by the WT1 Wilms tumor gene product

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Molecular cloning of rat Wilms' tumor complementary DNA and a study of messenger RNA expression in the urogenital system and the brain

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Role of ornithine decarboxylase in the regulation of cell growth by IL-1 and tumor necrosis factor.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231698

A third Wilms' tumor locus on chromosome 16q

29 November 2018

1 reference

12 December 2020

Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1

1 reference

12 December 2020

The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene

1 reference

12 December 2020

Phytanic acid alpha-oxidation. Differential subcellular localization in rat and human tissues and its inhibition by nycodenz

1 reference

12 December 2020

Characterization of regions of chromosomes 12 and 16 involved in nephroblastoma tumorigenesis

1 reference

12 December 2020

Identification of novel regions of deletion in familial Wilms' tumor by comparative genomic hybridization

1 reference

12 December 2020

Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.16.12.6945

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json

release_7kjfdi4wqretpe4cwxjtqa4wii

21 October 2019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7kjfdi4wqretpe4cwxjtqa4wii

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json

21 October 2019

PubMed publication ID

8943350

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8943350%20AND%20SRC:MED&resulttype=core&format=json