Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases (Q24313433)

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English	Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases	scientific article

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Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases (English)

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Cullin associated and neddylation dissociated 1

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GOA release 2020-03-11

author name string

Seth J Goldenberg

1

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Thomas C Cascio

2

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Stuart D Shumway

3

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Kenneth C Garbutt

4

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Jidong Liu

5

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Yue Xiong

6

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Ning Zheng

7

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language of work or name

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publication date

12 November 2004

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119

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4

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517-28

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Molecular cloning of a novel 120-kDa TBP-interacting protein

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Identification of NEDD8-conjugation site in human cullin-2

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).

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Comparison of ARM and HEAT protein repeats

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7 January 2021

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Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

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TIP120A associates with unneddylated cullin 1 and regulates its neddylation

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Processing of X-ray diffraction data collected in oscillation mode

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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

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cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

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Molecular architecture and functional model of the endocytic AP2 complex

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

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COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

1 reference

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Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.

1 reference

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A family of mammalian F-box proteins

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

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Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

1 reference

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases

1 reference

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based on heuristic

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The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila Oogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

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based on heuristic

inferred from DOI database lookup

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of importin-beta bound to the IBB domain of importin-alpha

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

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The F-box protein slimb controls the levels of clock proteins period and timeless

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Covalent modification of all members of human cullin family proteins by NEDD8

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Nedd8 on cullin: building an expressway to protein destruction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

An additional role for the F-box motif: gene regulation within the Neurospora crassa sulfur control network.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

TIP120A associates with cullins and modulates ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel protein modification pathway related to the ubiquitin system

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

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Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

A new NEDD8-ligating system for cullin-4A

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https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The COP9 Signalosome Interacts with SCFUFO and Participates in Arabidopsis Flower Development

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Accumulation of phosphorylated repressor for gibberellin signaling in an F-box mutant

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The abundance of cell cycle regulatory protein Cdc4p is controlled by interactions between its F box and Skp1p

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The ubiquitin system

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

SCF and Cullin/Ring H2-based ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The F-box protein family.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2004.10.019

7 January 2021

based on heuristic

inferred from DOI database lookup

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