Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations (Q24314844)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903587

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903589

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

2 references

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903588

GOA release 2020-03-11

Programmed cell death 10

1 reference

Delta like canonical Notch ligand 4

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Chao You

0 references

Ibrahim Erol Sandalcioglu

0 references

Philipp Dammann

0 references

Ute Felbor

0 references

Ulrich Sure

0 references

Yuan Zhu

Journal of Cellular and Molecular Medicine

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language of work or name

English

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publication date

March 2013

0 references

published in

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volume

0 references

issue

0 references

page(s)

407-18

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3823022/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress

1 reference

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CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

KRIT1 regulates the homeostasis of intracellular reactive oxygen species

19 March 2017

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Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

19 March 2017

1 reference

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Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

19 March 2017

1 reference

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CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

19 March 2017

1 reference

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A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

19 March 2017

1 reference

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CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

19 March 2017

1 reference

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PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway

19 March 2017

1 reference

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Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting

19 March 2017

1 reference

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Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations

19 March 2017

1 reference

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Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

19 March 2017

1 reference

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Notch signalling: a simple pathway becomes complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

27 September 2017

1 reference

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Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development

27 September 2017

1 reference

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Recent insights into cerebral cavernous malformations: the molecular genetics of CCM.

27 September 2017

1 reference

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Novel insights into the differential functions of Notch ligands in vascular formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

VEGF and Notch signaling: the yin and yang of angiogenic sprouting

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

VEGF Stimulates the ERK 1/2 signaling pathway and apoptosis in cerebral endothelial cells after ischemic conditions

27 September 2017

1 reference

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Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma

27 September 2017

1 reference

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Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

27 September 2017

1 reference

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Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Notch signaling in vascular development and physiology

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3823022

Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development

30 May 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Genotype-phenotype correlations in cerebral cavernous malformations patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Proteomic identification of the cerebral cavernous malformation signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Involvement of PTEN promoter methylation in cerebral cavernous malformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJCMM.12022

In Vitro Characterization of the Angiogenic Phenotype and Genotype of the Endothelia Derived From Sporadic Cerebral Cavernous Malformations

21 January 2018

1 reference

12 December 2020

The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions

1 reference

12 December 2020

The natural history of cavernous malformations: a prospective study of 68 patients

1 reference

12 December 2020

Spectrum of genotype and clinical manifestations in cerebral cavernous malformations

1 reference

12 December 2020

Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells

1 reference

12 December 2020

PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit

1 reference

12 December 2020

Identifiers

DOI

10.1111/JCMM.12022

1 reference

1 reference

1 reference

PubMed publication ID

23388056

1 reference