Skeletal overexpression of gremlin impairs bone formation and causes osteopenia (Q24314447)

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5 January 2020

title

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia (English)

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Gremlin 1, DAN family BMP antagonist

5 January 2020

main subject

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GOA release 2020-03-11

Noggin

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negative regulation of canonical Wnt signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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5 January 2020

Elisabetta Gazzerro

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5 January 2020

Renata C Pereira

series ordinal

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5 January 2020

Sarah Olson

series ordinal

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5 January 2020

Ernesto Canalis

series ordinal

1 reference

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5 January 2020

language of work or name

English

0 references

publication date

11 November 2004

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volume

146

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issue

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page(s)

655-665

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Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

5 January 2020

cites work

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7 January 2021

A mouse cerberus/Dan-related gene family

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In Xenopus embryos, BMP heterodimers are not required for mesoderm induction, but BMP activity is necessary for dorsal/ventral patterning

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7 January 2021

The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation

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Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

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7 January 2021

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

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7 January 2021

Twisted perspective: new insights into extracellular modulation of BMP signaling during development

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7 January 2021

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities

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7 January 2021

Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters.

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7 January 2021

Noggin arrests stromal cell differentiation in vitro☆☆This work was supported by Grant AR21707 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Grant DK45227 from the National Institute of Diabetes, Digestive an

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7 January 2021

BMP signaling components are expressed in human fracture callus

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Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine

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7 January 2021

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

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7 January 2021

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

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7 January 2021

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

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7 January 2021

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

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7 January 2021

Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes

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7 January 2021

Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva

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7 January 2021

Regulation of bone formation and vision by LRP5

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7 January 2021

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

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7 January 2021

Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption

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7 January 2021

Biosynthesis, post-translation modification, and functional characterization of Drm/Gremlin

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7 January 2021

Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family

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7 January 2021

Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype

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7 January 2021

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation

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7 January 2021

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

1 reference

https://api.crossref.org/works/10.1210%2FEN.2004-0766

7 January 2021

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

1 reference

https://api.crossref.org/works/10.1210%2FEN.2004-0766

7 January 2021

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

1 reference

https://api.crossref.org/works/10.1210%2FEN.2004-0766

7 January 2021

Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development

1 reference

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7 January 2021

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

1 reference

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7 January 2021

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning

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7 January 2021

Identification of drm, a Novel Gene Whose Expression Is Suppressed in Transformed Cells and Which Can Inhibit Growth of Normal but Not Transformed Cells in Culture

1 reference

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7 January 2021

Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts

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7 January 2021

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

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7 January 2021

Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid

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7 January 2021

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone

1 reference

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7 January 2021

Pre-osteoblastic Proliferation Assessed with BrdU in Undecalcified, Epon-embedded Adult Rat Trabecular Bone

1 reference

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7 January 2021

Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia

1 reference

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7 January 2021

Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

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7 January 2021

Notch 1 impairs osteoblastic cell differentiation

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7 January 2021

Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures

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7 January 2021

Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex.

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7 January 2021

Bone morphogenetic proteins, their antagonists, and the skeleton

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7 January 2021

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

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7 January 2021

Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor

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7 January 2021

Secreted antagonists of the Wnt signalling pathway

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7 January 2021

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

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7 January 2021

Validation of peripheral dual-energy X-ray absorptiometry for the measurement of bone mineral in intact and excised long bones of rats

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7 January 2021

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

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7 January 2021

Staining and Histochemistry of Undecalcified Bone Embedded in a Water-Miscible Plastic

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7 January 2021

Identifiers

DOI

10.1210/EN.2004-0766

2 references

Consolidated OpenCitations Corpus – April 2017

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5 January 2020

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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