Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7 (Q24301886)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

F-box and WD repeat domain containing 7

19 January 2020

main subject

1 reference

positive regulation of ubiquitin-dependent protein catabolic process

1 reference

Presenilin 2

1 reference

Epidermal growth factor receptor

1 reference

Presenilin 1

1 reference

F-box and WD-40 domain protein 7

1 reference

Epidermal growth factor

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

V Rocher-Ros

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

S Marco

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

S Gines

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

A Balmain

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

P Chambon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

8 March 2010

1 reference

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19 January 2020

1 reference

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19 January 2020

volume

1 reference

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19 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

2950-2961

1 reference

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describes a project that uses

19 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4162408/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase

1 reference

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Suppressor role of activating transcription factor 2 (ATF2) in skin cancer

19 March 2017

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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

19 March 2017

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SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production

19 March 2017

1 reference

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SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

19 March 2017

1 reference

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Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity

19 March 2017

1 reference

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SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells

19 March 2017

1 reference

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Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

19 March 2017

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Canonical notch signaling functions as a commitment switch in the epidermal lineage

19 March 2017

1 reference

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Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

19 March 2017

1 reference

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

19 March 2017

1 reference

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

19 March 2017

1 reference

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Skeletal and CNS defects in Presenilin-1-deficient mice

19 March 2017

1 reference

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Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

19 March 2017

1 reference

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gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

19 March 2017

1 reference

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

19 March 2017

1 reference

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Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Nonproteolytic functions of ubiquitin in cell signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Notch1 functions as a tumor suppressor in mouse skin

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer

7 April 2017

1 reference

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EGF receptor ubiquitination is not necessary for its internalization

27 September 2017

1 reference

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Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase

27 September 2017

1 reference

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Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

27 September 2017

1 reference

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Fbw7/hCDC4 dimerization regulates its substrate interactions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Epidermal growth factor receptor biology in head and neck cancer

27 September 2017

1 reference

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Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway

27 September 2017

1 reference

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Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression

27 September 2017

1 reference

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Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

27 September 2017

1 reference

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

GCF2: expression and molecular analysis of repression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

The EGF receptor - an essential regulator of multiple epidermal functions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Impaired notch signaling promotes de novo squamous cell carcinoma formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasome-dependent EGFR de-ubiquitination

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Functional characterization of novel presenilin-2 variants identified in human breast cancers

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Primary mouse keratinocyte culture

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Deregulated expression of LRBA facilitates cancer cell growth

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162408

29 November 2018

Identifiers

DOI

10.1038/ONC.2010.57

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 January 2020

1027702125

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

20208556

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20208556%20AND%20SRC:MED&resulttype=core&format=json