Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells (Q24300017)

KIT proto-oncogene, receptor tyrosine kinase

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membrane protein ectodomain proteolysis

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A disintegrin and metallopeptidase domain 17

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author name string

Anthony C Cruz

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Brendon T Frank

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Samuel T Edwards

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Paul F Dazin

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Jacques J Peschon

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Kenneth C Fang

Journal of Biological Chemistry

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language of work or name

English

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publication date

13 February 2004

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published in

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volume

279

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issue

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page(s)

5612-20

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cites work

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Serum levels of soluble stem cell factor and soluble KIT are elevated in patients with atopic dermatitis and correlate with the disease severity

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The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype

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The fifth immunoglobulin-like domain of the Kit receptor is required for proteolytic cleavage from the cell surface

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