Hepatitis C virus expression suppresses interferon signaling by degrading STAT1 (Q24300002)

negative regulation by virus of viral protein levels in host cell

GOA release 2020-03-11

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GOA release 2020-03-11

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Wenyu Lin

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Won Hyeok Choe

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Yoichi Hiasa

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Yoshitaka Kamegaya

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Jason T Blackard

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Emmett V Schmidt

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Raymond T Chung

The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein

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language of work or name

English

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publication date

April 2005

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published in

Gastroenterology

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volume

128

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issue

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page(s)

1034-41

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cites work

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7 January 2021

Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice

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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

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A weak signal for strong responses: interferon-alpha/beta revisited

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Clinical utility of total HCV core antigen quantification: a new indirect marker of HCV replication

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Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirin

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7 January 2021

The prevalence of hepatitis C virus infection in the United States, 1988 through 1994

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Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system

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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

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Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee

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7 January 2021

Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase

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An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A

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7 January 2021

Hepatitis C virus core protein differently regulates the JAK-STAT signaling pathway under interleukin-6 and interferon-gamma stimuli

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7 January 2021

A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response

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7 January 2021

Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1.

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7 January 2021

Suppression of interferon-induced antiviral activity in cells expressing hepatitis C virus proteins

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7 January 2021

IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3.

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7 January 2021

Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

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7 January 2021

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

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7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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7 January 2021

Antiviral actions of interferons

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7 January 2021

Hepatitis C virus structural proteins assemble into viruslike particles in insect cells

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7 January 2021

Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-STAT pathway

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7 January 2021

The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation

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7 January 2021

Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines

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7 January 2021

Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system

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7 January 2021

C-terminal region of STAT-1alpha is not necessary for its ubiquitination and degradation caused by mumps virus V protein

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7 January 2021

Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferons

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7 January 2021

Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells

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https://api.crossref.org/works/10.1053%2FJ.GASTRO.2005.02.006

7 January 2021

Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction

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7 January 2021

Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(i)-poly(c), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons

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7 January 2021

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

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https://api.crossref.org/works/10.1053%2FJ.GASTRO.2005.02.006

7 January 2021

Identification of a nuclear Stat1 protein tyrosine phosphatase

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https://api.crossref.org/works/10.1053%2FJ.GASTRO.2005.02.006

7 January 2021