Rap2A links intestinal cell polarity to brush border formation (Q24293320)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903697

positive regulation of microvillus assembly

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903698

protein localization to plasma membrane

1 reference

GOA release 2020-03-11

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Thijs Koorman

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Martijn Gloerich

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Jean Paul ten Klooster

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Marjolein J Vliem

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Fried J Zwartkruis

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Johannes L Bos

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

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language of work or name

English

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publication date

August 2012

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793-801

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cites work

1 reference

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

20 April 2017

1 reference

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

20 April 2017

1 reference

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast

20 April 2017

1 reference

Organizing the cell cortex: the role of ERM proteins

20 April 2017

1 reference

Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase

20 April 2017

1 reference

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton

20 April 2017

1 reference

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control

20 April 2017

1 reference

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

20 April 2017

1 reference

MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1

20 April 2017

1 reference

Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment

20 April 2017

1 reference

YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta

20 April 2017

1 reference

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

20 April 2017

1 reference

Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory

20 April 2017

1 reference

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

20 April 2017

1 reference

Lifeact: a versatile marker to visualize F-actin

20 April 2017

1 reference

Widely conserved signaling pathways in the establishment of cell polarity

20 April 2017

1 reference

STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.

21 January 2018

1 reference

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

1 reference

LKB1-dependent signaling pathways

21 January 2018

1 reference

Mechanisms of polarized growth and organelle segregation in yeast

21 January 2018

1 reference

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex

21 January 2018

1 reference

Phosphoinositides in cell architecture.

21 January 2018

1 reference

Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes

21 January 2018

1 reference

Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain

21 January 2018

1 reference

Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs.

21 January 2018

1 reference

Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1.

21 January 2018

1 reference

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

21 January 2018

1 reference

Membrane-dependent signal integration by the Ras activator Son of sevenless

21 January 2018

1 reference

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

21 January 2018

1 reference

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

21 January 2018

1 reference

Direct spatial control of Epac1 by cyclic AMP.

21 January 2018

1 reference

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

21 January 2018

1 reference

Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130.

21 January 2018

1 reference

Measurement of GTP-bound Ras-like GTPases by activation-specific probes

21 January 2018

1 reference

Binding of GAPR-1 to negatively charged phospholipid membranes: unusual binding characteristics to phosphatidylinositol

21 January 2018

1 reference

Phospholipase D1 Production of Phosphatidic Acid at the Plasma Membrane Promotes Exocytosis of Large Dense-core Granules at a Late Stage

21 January 2018

1 reference

Monitoring Agonist-induced Phospholipase C Activation in Live Cells by Fluorescence Resonance Energy Transfer

21 January 2018

1 reference

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22797597

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Basic culture methods

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22797597

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22797597