Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor (Q24291702)

negative regulation of angiogenesis

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

neurite

1 reference

inferred from title

angiogenesis inhibitor

1 reference

M Simonovic

Simonovic

1 reference

19 October 2023

P G Gettins

series ordinal

author given names

P G

author last names

Gettins

1 reference

19 October 2023

K Volz

series ordinal

author given names

author last names

Volz

1 reference

Proceedings of the National Academy of Sciences of the United States of America

19 October 2023

language of work or name

English

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publication date

25 September 2001

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published in

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volume

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issue

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page(s)

11131-5

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cites work

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Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state

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Multiple sequence alignment with hierarchical clustering

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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Pigment epithelium-derived factor: a potent inhibitor of angiogenesis

19 March 2017

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Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop

19 March 2017

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Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells

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PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity

19 March 2017

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Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration

19 March 2017

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Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor

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Regulation of EPC-1/PEDF in normal human fibroblasts is posttranscriptional.

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Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

27 September 2017

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Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor.

27 September 2017

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Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

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Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons

27 September 2017

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Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin

30 May 2018

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Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations

30 May 2018

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Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity

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Pigment epithelium-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes

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PEDF: Raising both hopes and questions in controlling angiogenesis

21 January 2018

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Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor.

21 January 2018

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[26] Screening for heavy-atom derivatives and obtaining accurate isomorphous differences.

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21 January 2018

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Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death

21 January 2018

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Differentiation of Y79 retinoblastoma cells with pigment epithelial-derived factor and interphotoreceptor matrix wash: effects on tumorigenicity

29 November 2018

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Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture

21 January 2018

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Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons

21 January 2018

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Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations

21 January 2018

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Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal

21 January 2018

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12 December 2020

Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity

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Proteolytic activity directed toward pigment epithelium-derived factor in vitreous of bovine eyes. Implications of proteolytic processing

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Identifiers

DOI

10.1073/PNAS.211268598

1 reference

release_okiiwons75hcjejm4wprybylda

0 references

0 references

2066920

1 reference

1 reference

2066920

1 reference