DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage (Q24299608)

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Naoe Taira

0 references

Keishi Nihira

0 references

Tomoko Yamaguchi

0 references

Yoshio Miki

0 references

Kiyotsugu Yoshida

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

0 references

language of work or name

English

0 references

publication date

9 March 2007

0 references

0 references

0 references

0 references

725-38

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

The p53 response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

ATM and ATR: networking cellular responses to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

DNA mismatch repair and cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Oxidants, oxidative stress and the biology of ageing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Genome maintenance mechanisms for preventing cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Post-translational modification of p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Determination of the specific substrate sequence motifs of protein kinase C isozymes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Substrate specificities and identification of putative substrates of ATM kinase family members

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Specificity determinants of substrate recognition by the protein kinase DYRK1A

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2007.02.007

7 January 2021