Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas (Q24299520)

GOA release 2020-03-11

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David A Tuveson

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Volkan Adsay

object named as

N Volkan Adsay

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ORCID Public Data File 2021

author name string

Kamel Izeradjene

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Chelsea Combs

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Melissa Best

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Aarthi Gopinathan

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Amary Wagner

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William M Grady

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Chu-Xia Deng

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Sunil R Hingorani

Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients

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language of work or name

English

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publication date

March 2007

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229-43

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

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STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas

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Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas

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Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

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Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

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Mouse models of pancreatic cancer: the fur is finally flying!

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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Stromal fibroblasts in cancer initiation and progression

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Wildtype Kras2 can inhibit lung carcinogenesis in mice

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The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

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Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

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TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines

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Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

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TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

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Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression

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Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas

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The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis.

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An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

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Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

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