TORCs: transducers of regulated CREB activity (Q24297430)

positive regulation of transcription by RNA polymerase II

GOA release 2020-03-11

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GOA release 2020-03-11

Robert Screaton

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Ernesto Carmona Guzmán

object named as

Ernesto Guzman

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author name string

Michael D Conkright

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Gianluca Canettieri

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Loren Miraglia

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John B Hogenesch

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Marc Montminy

Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation

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language of work or name

English

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publication date

August 2003

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413-23

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cites work

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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

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The regulation of transcription by phosphorylation

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Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness

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Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors

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Phosphorylated CREB binds specifically to the nuclear protein CBP

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t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

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Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex

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A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

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Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation

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The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells

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The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex

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The CREB constitutive activation domain interacts with TATA-binding protein-associated factor 110 (TAF110) through specific hydrophobic residues in one of the three subdomains required for both activation and TAF110 binding

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Stimulus-specific interaction between activator-coactivator cognates revealed with a novel complex-specific antiserum

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The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators

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Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors

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The mammalian gene collection

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Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

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The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

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Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism

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Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators

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A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos

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Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo

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Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB.

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