Personalized medicine: hope or hype? (Q24289193)

inferred from title

author

Hugh Christian Watkins

Hugh Watkins

Hugh

Watkins

1 reference

19 October 2023

Keyan Salari

Keyan

Salari

1 reference

22659199

19 October 2023

Euan A Ashley

series ordinal

author given names

Euan A

author last names

Ashley

1 reference

22659199

Phased whole-genome genetic risk in a family quartet using a major allele reference sequence

19 October 2023

language of work or name

English

0 references

publication date

July 2012

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published in

European Heart Journal

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volume

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issue

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page(s)

1564-70

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cites work

1 reference

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19 March 2017

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The dawning era of personalized medicine exposes a gap in medical education

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19 March 2017

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19 March 2017

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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

19 March 2017

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Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction

19 March 2017

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19 March 2017

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Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

19 March 2017

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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

19 March 2017

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Common SNPs explain a large proportion of the heritability for human height

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning

27 September 2017

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Synthetic associations are unlikely to account for many common disease genome-wide association signals

27 September 2017

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Synthetic associations created by rare variants do not explain most GWAS results

27 September 2017

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The reference human genome demonstrates high risk of type 1 diabetes and other disorders.

27 September 2017

1 reference

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A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

27 September 2017

1 reference

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Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

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27 September 2017

1 reference

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Performance of common genetic variants in breast-cancer risk models

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy

27 September 2017

1 reference

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Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study

27 September 2017

1 reference

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Estimation of the warfarin dose with clinical and pharmacogenetic data

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Cytochrome p-450 polymorphisms and response to clopidogrel

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Genetic determinants of response to clopidogrel and cardiovascular events

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Clinical risk factors, DNA variants, and the development of type 2 diabetes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Genotype score in addition to common risk factors for prediction of type 2 diabetes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

CYP4F2 genetic variant alters required warfarin dose

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Use and misuse of the receiver operating characteristic curve in risk prediction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

PolyDoms: a whole genome database for the identification of non-synonymous coding SNPs with the potential to impact disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Effects of CYP2C19 genotype on outcomes of clopidogrel treatment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Genetic variants associated with Lp(a) lipoprotein level and coronary disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

The Human Gene Mutation Database: 2008 update

30 May 2018

1 reference

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Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

De novo mutations of SETBP1 cause Schinzel-Giedion syndrome

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study).

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Polymorphisms associated with cholesterol and risk of cardiovascular events

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3388016

No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22659199

12 December 2020

inferred from PubMed ID database lookup

Challenges in the clinical application of whole-genome sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/22659199

12 December 2020

inferred from PubMed ID database lookup

Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22659199

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/EURHEARTJ/EHS112

1 reference

release_2gzxra5ow5fgrcfccheg5wcoba

Fatcat ID

0 references

1 reference

1 reference

22659199

1 reference