Apolipoprotein A1 (Q1316030)

http://www.ebi.ac.uk/interpro/protein/P02647

image of molecular model or crystal lattice model

PBB Protein APOA1 image.jpg
500 × 500; 57 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

lipase inhibitor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

phosphatidylcholine binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

1 reference

3 January 2017

apolipoprotein receptor binding

1 reference

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

high-density lipoprotein particle receptor binding

lipoprotein particle binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

phosphatidylcholine-sterol O-acyltransferase activator activity

1 reference

3 January 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

phospholipid binding

1 reference

3 January 2017

Structure and interfacial properties of human apolipoprotein A-V

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

apolipoprotein A-I receptor binding

1 reference

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

enzyme binding

1 reference

8 April 2019

Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cholesterol transfer activity

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

3 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

amyloid-beta binding

1 reference

3 January 2017

Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

phospholipid transporter activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

protein binding

13 references

8 April 2019

Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

An investigation into the human serum "interactome"

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Haptoglobin binds the antiatherogenic protein apolipoprotein E - impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

Alzheimers Project at University of Toronto

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

chemorepellent activity

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

lipid transporter activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cholesterol binding

1 reference

3 January 2017

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

identical protein binding

Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Identification of an amyloid fibril forming peptide comprising residues 46-59 of apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Structural and functional properties of human and mouse apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

high-density lipoprotein particle binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

amyloid-beta binding

Association of human, rat, and rabbit apolipoprotein E with ?-amyloid

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cholesterol binding

cholesterol transfer activity

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

heat shock protein binding

1 reference

8 April 2019

Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

high-density lipoprotein particle receptor binding

Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

signaling receptor binding

1 reference

8 April 2019

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

endoplasmic reticulum lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

chylomicron

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

extracellular region

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

extracellular vesicle

1 reference

3 January 2017

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

endocytic vesicle lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

discoidal high-density lipoprotein particle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

very-low-density lipoprotein particle

1 reference

8 April 2019

Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cell surface

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

secretory granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

extracellular exosome

4 references

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

blood microparticle

1 reference

3 January 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

endocytic vesicle

1 reference

8 April 2019

The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

spherical high-density lipoprotein particle

1 reference

8 April 2019

Isolation and characterization of human apolipoprotein M-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

early endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

high-density lipoprotein particle

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

5 references

3 January 2017

3 January 2017

Apoprotein (E–A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

cytoplasmic vesicle

1 reference

8 April 2019

ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

extracellular space

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

6 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

extracellular space

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

low-density lipoprotein particle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

intermediate-density lipoprotein particle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

high-density lipoprotein particle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

8 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

1 January 2018

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

1 January 2018

Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

1 January 2018

Apoprotein (E–A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

1 January 2018

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

1 January 2018

Association of human, rat, and rabbit apolipoprotein E with ?-amyloid

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02647&geneProductId=UniProtKB:P02647

collagen-containing extracellular matrix

1 reference

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

extracellular exosome

3 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

blood microparticle

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

extracellular vesicle

1 reference

8 April 2019

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

high-density lipoprotein particle

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Apoprotein (E–A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Association of human, rat, and rabbit apolipoprotein E with ?-amyloid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of Rho protein signal transduction

biological process

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cholesterol import

1 reference

8 April 2019

Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

negative chemotaxis

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of cholesterol esterification

1 reference

3 January 2017

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

phospholipid transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

negative regulation of hydrolase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

receptor-mediated endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

retinoid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

negative regulation of lipase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

negative regulation of cell adhesion molecule production

1 reference

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

peripheral nervous system axon regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

animal organ regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

peptidyl-methionine modification

1 reference

8 April 2019

Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cholesterol homeostasis

negative regulation of heterotypic cell-cell adhesion

1 reference

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

negative regulation of inflammatory response

1 reference

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

phospholipid homeostasis

1 reference

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

ERK1 and ERK2 cascade

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

negative regulation of cytokine production involved in immune response

1 reference

8 April 2019

Apolipoproteins A-I and A-II downregulate neutrophil functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of fatty acid biosynthetic process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

1 reference

3 January 2017

high-density lipoprotein particle clearance

1 reference

3 January 2017

Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

lipoprotein metabolic process

G protein-coupled receptor signaling pathway

3 references

1 reference

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of triglyceride catabolic process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

1 reference

3 January 2017

response to nutrient

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

glucocorticoid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

lipid storage

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

protein stabilization

positive regulation of lipoprotein lipase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

1 reference

3 January 2017

cholesterol metabolic process

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

response to estrogen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

triglyceride catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

transport

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

1 reference

3 January 2017

cholesterol efflux

ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells

7 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

Scavenger receptor SR-BI in macrophage lipid metabolism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

3 January 2017

ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

integrin-mediated signaling pathway

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

phosphatidylcholine biosynthetic process

1 reference

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

neuron projection regeneration

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

1 reference

3 January 2017

negative regulation of very-low-density lipoprotein particle remodeling

1 reference

8 April 2019

Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

positive regulation of hydrolase activity

1 reference

8 April 2019

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

regulation of Cdc42 protein signal transduction

1 reference

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

blood vessel endothelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

negative regulation of tumor necrosis factor-mediated signaling pathway

1 reference

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

platelet degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

adrenal gland development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

high-density lipoprotein particle assembly

1 reference

3 January 2017

Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

negative regulation of response to cytokine stimulus

1 reference

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of substrate adhesion-dependent cell spreading

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

phospholipid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

vitamin transport

1 reference

8 April 2019

Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of stress fiber assembly

1 reference

8 April 2019

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

triglyceride homeostasis

1 reference

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

reverse cholesterol transport

1 reference

3 January 2017

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P02647

positive regulation of cholesterol efflux

1 reference

8 April 2019

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

regulation of lipid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

regulation of intestinal cholesterol absorption

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

regulation of cholesterol transport

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cholesterol efflux

ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Scavenger receptor SR-BI in macrophage lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

phospholipid efflux

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

chylomicron remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

very-low-density lipoprotein particle remodeling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

high-density lipoprotein particle remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

3 references

8 April 2019

8 April 2019

Scavenger receptor SR-BI in macrophage lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

A protein cofactor of lecithin:cholesterol acyltransferase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

chylomicron assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

high-density lipoprotein particle assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

3 references

8 April 2019

8 April 2019

Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

lipoprotein biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

cholesterol homeostasis

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

post-translational protein modification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

1 reference

8 April 2019

reverse cholesterol transport

positive regulation of lipid biosynthetic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of phagocytosis

1 reference

8 April 2019

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

positive regulation of phospholipid efflux

1 reference

8 April 2019

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02647

https://docs.openalex.org/download-snapshot/snapshot-data-format

Gene Atlas image

PBB GE APOA1 204450 x at fs.png
732 × 530; 8 KB

0 references

Identifiers

MeSH descriptor ID

D016632

subject named as

Apolipoprotein A-I

0 references

MeSH tree code

D10.532.091.200.100

0 references

D12.776.070.400.200.100

0 references

D12.776.521.120.200.100

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016