Mitogen-activated protein kinase 1 (Q15317763)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63085

mitogen-activated protein (MAP) kinase, ERK1/2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63085

membrane protein

1 reference

inferred from GOA cell component → membrane

Protein kinase domain, protein family

1 reference

Mitogen-activated protein (MAP) kinase, conserved site, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

31 January 2018

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

3 references

8 April 2019

8 April 2019

Gab1 is an integrator of cell death versus cell survival signals in oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

phosphotyrosine residue binding

1 reference

8 April 2019

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

protein binding

15 references

8 April 2019

Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

RNA polymerase II CTD heptapeptide repeat kinase activity

1 reference

8 April 2019

A Novel RNA Polymerase II C-terminal Domain Phosphatase That Preferentially Dephosphorylates Serine 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

mitogen-activated protein kinase kinase kinase binding

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

transcription factor binding

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

5 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

1 January 2018

Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

MAP kinase activity

Role of the nude gene in epithelial terminal differentiation

12 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

ERK is a novel regulatory kinase for poly(A) polymerase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

ERK is a novel regulatory kinase for poly(A) polymerase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

ATP binding

3 references

protein kinase binding

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

identical protein binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

MAP kinase activity

14 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Role of the nude gene in epithelial terminal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

ERK is a novel regulatory kinase for poly(A) polymerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

ERK is a novel regulatory kinase for poly(A) polymerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

MAP kinase kinase activity

1 reference

8 April 2019

Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

ATP binding

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

phosphatase binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

protein serine/threonine kinase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cell component

cytoplasm

7 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

focal adhesion

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

microtubule organizing center

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

mitochondrion

nucleus

The ERK signaling cascade--views from different subcellular compartments

8 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

late endosome

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

Golgi apparatus

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

spindle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

early endosome

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

mitotic spindle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

ISS

pseudopodium

1 reference

8 April 2019

A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

axon

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

dendrite cytoplasm

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

cytosol

The ERK signaling cascade--views from different subcellular compartments

5 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

perikaryon

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

caveola

The ERK signaling cascade--views from different subcellular compartments

4 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

16 September 2017

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63085&geneProductId=UniProtKB:P63085

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

nucleus

The ERK signaling cascade--views from different subcellular compartments

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

nucleoplasm

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cytosol

The ERK signaling cascade--views from different subcellular compartments

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

plasma membrane

The ERK signaling cascade--views from different subcellular compartments

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

caveolin-mediated endocytosis

biological process

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

response to exogenous dsRNA

1 reference

8 April 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cardiac neural crest cell development involved in heart development

1 reference

8 April 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cellular response to DNA damage stimulus

1 reference

8 April 2019

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

protein phosphorylation

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Role of the nude gene in epithelial terminal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

face development

cellular response to granulocyte macrophage colony-stimulating factor stimulus

1 reference

8 April 2019

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

animal organ morphogenesis

1 reference

8 April 2019

Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

B cell receptor signaling pathway

1 reference

8 April 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

ISS

thymus development

1 reference

8 April 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

negative regulation of cell differentiation

1 reference

8 April 2019

Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

ERK1 and ERK2 cascade

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

labyrinthine layer blood vessel development

1 reference

8 April 2019

Essential role for ERK2 mitogen-activated protein kinase in placental development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

transcription, DNA-templated

1 reference

8 April 2019

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

positive regulation of transcription, DNA-templated

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

heart development

1 reference

8 April 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of ossification

1 reference

8 April 2019

Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of stress-activated MAPK cascade

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cytosine metabolic process

1 reference

8 April 2019

MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

1 reference

8 April 2019

outer ear morphogenesis

1 reference

8 April 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

response to lipopolysaccharide

1 reference

8 April 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

thyroid gland development

1 reference

8 April 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

response to epidermal growth factor

ISS

peptidyl-threonine phosphorylation

1 reference

8 April 2019

Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

trachea formation

1 reference

8 April 2019

Crucial requirement of ERK/MAPK signaling in respiratory tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

mammary gland epithelial cell proliferation

1 reference

8 April 2019

IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

lung morphogenesis

1 reference

8 April 2019

Crucial requirement of ERK/MAPK signaling in respiratory tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

neural crest cell development

1 reference

8 April 2019

Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

positive regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of early endosome to late endosome transport

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

peptidyl-serine phosphorylation

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

ERK is a novel regulatory kinase for poly(A) polymerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

ERK is a novel regulatory kinase for poly(A) polymerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

Bergmann glial cell differentiation

1 reference

8 April 2019

Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of Golgi inheritance

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

T cell receptor signaling pathway

1 reference

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of cytoskeleton organization

1 reference

8 April 2019

The ERK signaling cascade--views from different subcellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

long-term potentiation

1 reference

8 April 2019

Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

response to estrogen

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

cellular response to organic substance

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

response to toxic substance

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

positive regulation of translation

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

intracellular signal transduction

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

sensory perception of pain

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

signal transduction

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

MAPK cascade

4 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

14 February 2017

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P63085

regulation of gene expression

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

MAPK cascade

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

The motheaten mutation rescues B cell signaling and development in CD45-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

regulation of cellular pH

1 reference

8 April 2019

Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

response to nicotine

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

intracellular signal transduction

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cellular response to organic substance

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

cellular response to tumor necrosis factor

1 reference

8 April 2019

MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085

positive regulation of protein import into nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63085