Signal transducer and activator of transcription 3 (Q14912021)

STAT transcription factor, DNA-binding, N-terminal

1 reference

transcription factor STAT

1 reference

STAT transcription factor, coiled coil

1 reference

SH2 domain superfamily

1 reference

STAT transcription factor, N-terminal domain superfamily

1 reference

STAT transcription factor, protein interaction, protein family

1 reference

SH2 domain, protein family

1 reference

STAT transcription factor, DNA-binding domain, protein family

1 reference

STAT3, SH2 domain, protein family

1 reference

STAT transcription factor, all-alpha domain, protein family

1 reference

protein dimerization activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

transcription factor binding

26 references

9 May 2019

Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

BART is essential for nuclear retention of STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Cross-talk between KLF4 and STAT3 regulates axon regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Bioinformatics and cellular signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Crif1 is a novel transcriptional coactivator of STAT3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Physical and functional interactions between STAT3 and ZIP kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

DNA-binding transcription factor activity, RNA polymerase II-specific

2 references

9 May 2019

Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

chromatin DNA binding

protein kinase binding

1 reference

9 May 2019

Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

DNA-binding transcription factor activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

protein homodimerization activity

1 reference

9 May 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

identical protein binding

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

DNA binding

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear Translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

sequence-specific DNA binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

cell component

cytoplasm

10 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear Translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Expression and activation of STAT proteins during mouse retina development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

plasma membrane

1 reference

9 May 2019

Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

nucleoplasm

14 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Expression and activation of STAT proteins during mouse retina development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

cytosol

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

Schaffer collateral - CA1 synapse

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

glutamatergic synapse

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

transcription regulator complex

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

nucleus

15 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Expression and activation of STAT proteins during mouse retina development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

negative regulation of neuron migration

biological process

1 reference

9 May 2019

The metabolite GnRH-(1-5) inhibits the migration of immortalized GnRH neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

receptor signaling pathway via JAK-STAT

TAS

1 reference

14 February 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

negative regulation of glycolytic process

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

regulation of transcription, DNA-templated

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

sexual reproduction

1 reference

9 May 2019

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

eating behavior

1 reference

9 May 2019

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

protein import into nucleus

1 reference

9 May 2019

Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

glucose homeostasis

regulation of multicellular organism growth

1 reference

9 May 2019

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

cytokine-mediated signaling pathway

NAS

1 reference

14 February 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

leptin-mediated signaling pathway

NAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

human ageing

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

response to peptide hormone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

regulation of feeding behavior

1 reference

9 May 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

transcription by RNA polymerase II

1 reference

9 May 2019

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

response to organic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

1 reference

16 July 2018

cellular response to leptin stimulus

regulation of cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

radial glial cell differentiation

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

stem cell population maintenance

1 reference

9 May 2019

Mediator and cohesin connect gene expression and chromatin architecture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

interleukin-6-mediated signaling pathway

astrocyte differentiation

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

eye photoreceptor cell differentiation

1 reference

9 May 2019

Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

energy homeostasis

1 reference

9 May 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

temperature homeostasis

1 reference

9 May 2019

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

cell population proliferation

1 reference

9 May 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

response to leptin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

response to ethanol

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

1 reference

9 May 2019

negative regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of Notch signaling pathway

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of transcription by RNA polymerase II

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

negative regulation of stem cell differentiation

1 reference

9 May 2019

Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of gene expression

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

mRNA transcription by RNA polymerase II

1 reference

9 May 2019

Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

inflammatory response

1 reference

9 May 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of transcription, DNA-templated

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

T-helper 17 cell lineage commitment

1 reference

9 May 2019

Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of erythrocyte differentiation

positive regulation of pri-miRNA transcription by RNA polymerase II

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of angiogenesis

1 reference

9 May 2019

Mmu-miR-351 attenuates the survival of cardiac arterial endothelial cells through targeting STAT3 in the atherosclerotic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

growth hormone receptor signaling pathway via JAK-STAT

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

14 February 2019

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of vascular endothelial cell proliferation

1 reference

9 May 2019

Mmu-miR-351 attenuates the survival of cardiac arterial endothelial cells through targeting STAT3 in the atherosclerotic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

modulation of chemical synaptic transmission

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

postsynapse to nucleus signaling pathway

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

positive regulation of cell migration

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

positive regulation of NF-kappaB transcription factor activity

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

negative regulation of autophagy

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42227&geneProductId=UniProtKB:P42227

defense response

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

TAS

leptin-mediated signaling pathway

NAS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

6 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

regulation of cell population proliferation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

positive regulation of transcription by RNA polymerase II

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

growth hormone receptor signaling pathway via JAK-STAT

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42227

STAT transcription factor, DNA-binding

has part(s)

1 reference

SH2 domain

1 reference

STAT transcription factor, all-alpha domain

1 reference

STAT transcription factor, protein interaction

1 reference

STAT3, SH2 domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016