GLI-Kruppel family member GLI3 (Q14886933)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61602

Zinc finger C2H2 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61602

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

DNA-binding transcription factor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

1 reference

14 February 2019

chromatin binding

1 reference

14 February 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

protein binding

8 references

14 February 2019

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

1 reference

14 February 2019

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

1 reference

14 February 2019

sequence-specific DNA binding

1 reference

14 February 2019

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

mediator complex binding

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61602&geneProductId=UniProtKB:Q61602

cell component

cytoplasm

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

transcription repressor complex

1 reference

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

nucleus

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

nuclear speck

1 reference

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

1 reference

14 February 2019

cilium

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Functional characterization of putative cilia genes by high-content analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

axoneme

1 reference

14 February 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

1 reference

14 February 2019

TAS

mediator complex

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61602&geneProductId=UniProtKB:Q61602

pattern specification process

biological process

1 reference

14 February 2019

Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

embryonic skeletal system morphogenesis

1 reference

14 February 2019

Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

lateral semicircular canal development

1 reference

14 February 2019

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

negative regulation of neuron differentiation

1 reference

14 February 2019

Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

tongue development

1 reference

14 February 2019

Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

optic nerve morphogenesis

1 reference

14 February 2019

Complementary Gli activity mediates early patterning of the mouse visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

smoothened signaling pathway involved in ventral spinal cord interneuron specification

1 reference

14 February 2019

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

anatomical structure formation involved in morphogenesis

1 reference

14 February 2019

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

hindgut morphogenesis

1 reference

14 February 2019

Anorectal malformations caused by defects in sonic hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

spinal cord dorsal/ventral patterning

oligodendrocyte differentiation

1 reference

14 February 2019

Specific requirements of sonic hedgehog signaling during oligodendrocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

mammary gland development

1 reference

14 February 2019

Gli3-mediated repression of Hedgehog targets is required for normal mammary development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

odontogenesis of dentin-containing tooth

1 reference

14 February 2019

The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

positive regulation of chondrocyte differentiation

1 reference

14 February 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

embryonic digestive tract morphogenesis

1 reference

14 February 2019

Gli3 null mice display glandular overgrowth of the developing stomach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

inner ear development

1 reference

14 February 2019

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

metanephros development

1 reference

14 February 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

melanocyte differentiation

1 reference

14 February 2019

A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

negative regulation of cell population proliferation

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

regulation of apoptotic process

1 reference

14 February 2019

Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

positive regulation of neuroblast proliferation

1 reference

14 February 2019

The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

limb morphogenesis

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

kidney development

1 reference

14 February 2019

Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

lung development

tube development

1 reference

14 February 2019

Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

embryonic organ development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

1 reference

14 February 2019

lateral ganglionic eminence cell proliferation

1 reference

14 February 2019

The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

negative regulation of cell differentiation

1 reference

14 February 2019

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

embryonic digit morphogenesis

A crucial role for primary cilia in cortical morphogenesis

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Hoxd and Gli3 interactions modulate digit number in the amniote limb

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

in utero embryonic development

1 reference

14 February 2019

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61602&geneProductId=UniProtKB:Q61602

1 reference

5 June 2018

heart development

1 reference

14 February 2019

Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

central nervous system development

telencephalon development

3 references

14 February 2019

A crucial role for primary cilia in cortical morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

embryonic limb morphogenesis

Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Twist plays an essential role in FGF and SHH signal transduction during mouse limb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

neural tube development

1 reference

14 February 2019

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

positive regulation of protein import into nucleus

1 reference

14 February 2019

Hedgehog-regulated localization of Vax2 controls eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

smoothened signaling pathway

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Hedgehog-regulated localization of Vax2 controls eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

camera-type eye development

1 reference

14 February 2019

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

spinal cord motor neuron differentiation

1 reference

14 February 2019

Complex interactions between genes controlling trafficking in primary cilia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

lambdoid suture morphogenesis

1 reference

14 February 2019

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

regulation of bone development

1 reference

14 February 2019

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

roof of mouth development

1 reference

14 February 2019

Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

anatomical structure development

1 reference

14 February 2019

Anorectal malformations caused by defects in sonic hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

wound healing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

negative regulation of apoptotic process

1 reference

14 February 2019

Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

response to estrogen

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

cerebral cortex radial glia-guided migration

1 reference

14 February 2019

Local disturbance of neuronal migration in the S-100beta-retarded mutant mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

positive regulation of osteoblast differentiation

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

developmental growth

1 reference

14 February 2019

Evidence for the Involvement of theGliGene Family in Embryonic Mouse Lung Development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

pallium development

1 reference

14 February 2019

Gli3 is required for Emx gene expression during dorsal telencephalon development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

mammary gland specification

1 reference

14 February 2019

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

frontal suture morphogenesis

1 reference

14 February 2019

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

regulation of gene expression

1 reference

14 February 2019

Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

anterior semicircular canal development

1 reference

14 February 2019

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

negative regulation of transcription, DNA-templated

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

dorsal/ventral pattern formation

Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

branching morphogenesis of an epithelial tube

1 reference

14 February 2019

Gli3 null mice display glandular overgrowth of the developing stomach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

embryonic digestive tract development

1 reference

14 February 2019

New mouse models of congenital anorectal malformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

subpallium development

1 reference

14 February 2019

The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

sagittal suture morphogenesis

1 reference

14 February 2019

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

forebrain dorsal/ventral pattern formation

1 reference

14 February 2019

Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

protein processing

1 reference

14 February 2019

A crucial role for primary cilia in cortical morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

axon guidance

brain development

3 references

14 February 2019

Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

smoothened signaling pathway involved in dorsal/ventral neural tube patterning

forebrain radial glial cell differentiation

1 reference

14 February 2019

Local disturbance of neuronal migration in the S-100beta-retarded mutant mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

regulation of cell population proliferation

1 reference

14 February 2019

Temporomandibular joint formation and condyle growth require Indian hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

1 reference

14 February 2019

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

layer formation in cerebral cortex

1 reference

14 February 2019

Gli3 is required for maintenance and fate specification of cortical progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

embryonic morphogenesis

1 reference

14 February 2019

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

artery development

1 reference

14 February 2019

Arteries define the position of the thyroid gland during its developmental relocalisation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

cell differentiation involved in kidney development

1 reference

14 February 2019

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

regulation of cell differentiation

1 reference

14 February 2019

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

forebrain development

1 reference

14 February 2019

Gli3 is required for the specification and differentiation of preplate neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

neuron fate commitment

1 reference

14 February 2019

Gli3 is required for the specification and differentiation of preplate neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

hippocampus development

1 reference

14 February 2019

Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

camera-type eye morphogenesis

1 reference

14 February 2019

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

anterior/posterior pattern specification

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

positive regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

thymocyte apoptotic process

1 reference

14 February 2019

The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

negative regulation of smoothened signaling pathway

1 reference

14 February 2019

The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

positive regulation of transcription, DNA-templated

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

14 February 2019

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

limb development

1 reference

14 February 2019

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

positive regulation of alpha-beta T cell differentiation

1 reference

14 February 2019

The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

negative regulation of alpha-beta T cell differentiation

1 reference

14 February 2019

The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

T cell differentiation in thymus

negative thymic T cell selection

1 reference

14 February 2019

The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

prostate gland development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

liver regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61602

has part(s)

Zinc finger C2H2-type

1 reference

InterPro Release 71.0