Pages that link to "Q35874372"
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The following pages link to First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms (Q35874372):
Displaying 33 items.
- A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP (Q27314017) (← links)
- Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration (Q27331605) (← links)
- Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease (Q27674362) (← links)
- Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? (Q28828789) (← links)
- Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780. (Q33944771) (← links)
- A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease (Q34376103) (← links)
- Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions (Q34384785) (← links)
- The γ-secretase complex: from structure to function (Q34677532) (← links)
- Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development (Q34876944) (← links)
- Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH (Q35212630) (← links)
- Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production (Q36294856) (← links)
- Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption (Q36489227) (← links)
- Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice (Q36614269) (← links)
- γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin (Q36742200) (← links)
- The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers (Q37062574) (← links)
- Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. (Q37062579) (← links)
- Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease (Q37559812) (← links)
- Therapeutic implications of the prostaglandin pathway in Alzheimer's disease (Q37678539) (← links)
- Development and mechanism of γ-secretase modulators for Alzheimer's disease (Q38101383) (← links)
- NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents (Q38790207) (← links)
- Initial Optimization of a New Series of γ-Secretase Modulators Derived from a Triterpene Glycoside (Q39736750) (← links)
- Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production (Q42703925) (← links)
- Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology. (Q44967903) (← links)
- Allosteric Modulation of Intact γ-Secretase Structural Dynamics (Q47270654) (← links)
- Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy (Q48273082) (← links)
- Generation and Partial Characterization of Rabbit Monoclonal Antibody to Amyloid-β Peptide 1-37 (Aβ37). (Q48299006) (← links)
- Structural and Chemical Biology of Presenilin Complexes (Q51093204) (← links)
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects. (Q53459259) (← links)
- Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays (Q60303067) (← links)
- Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer's Disease (Q89804772) (← links)
- The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation (Q91559566) (← links)
- NGP 555, a γ-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses (Q92543603) (← links)
- Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease (Q97570180) (← links)