intercellular adhesion molecule 1 (Q3146527)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05362

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05362

Immunoglobulin subtype, protein family

1 reference

Intercellular adhesion molecule, N-terminal domain, protein family

1 reference

Intercellular adhesion molecule

1 reference

Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal domain, protein family

1 reference

image

ICAM1.png
1,920 × 975; 517 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

virus receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

1 reference

8 April 2019

integrin binding

Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

protein binding

5 references

8 April 2019

CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

CD98 and Intracellular Adhesion Molecule I Regulate the Activity of Amino Acid Transporter LAT-2 in Polarized Intestinal Epithelia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Structural recognition of a novel fibrinogen gamma chain sequence (117-133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

transmembrane signaling receptor activity

1 reference

8 April 2019

The major human rhinovirus receptor is ICAM-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

integrin binding

Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

signaling receptor activity

IBA

1 reference

8 April 2019

The major human rhinovirus receptor is ICAM-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

focal adhesion

1 reference

31 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

3 references

8 April 2019

8 April 2019

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

integral component of plasma membrane

1 reference

31 October 2017

The major human rhinovirus receptor is ICAM-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

cell surface

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

Quantitative proteomics identifies a Dab2/integrin module regulating cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

immunological synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

extracellular exosome

3 references

31 October 2017

Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

external side of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

extracellular matrix

1 reference

31 October 2017

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

focal adhesion

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cell surface

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Quantitative proteomics identifies a Dab2/integrin module regulating cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

membrane

collagen-containing extracellular matrix

3 references

1 reference

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

extracellular exosome

Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to ionizing radiation

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

establishment of endothelial barrier

IGI

1 reference

8 April 2019

MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

negative regulation of endothelial cell apoptotic process

IGI

1 reference

8 April 2019

Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

1 reference

8 April 2019

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to amino acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

positive regulation of actin filament polymerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

T cell antigen processing and presentation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

establishment of Sertoli cell barrier

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to sulfur dioxide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to copper ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

interferon-gamma-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

1 reference

8 April 2019

positive regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to amphetamine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

regulation of leukocyte mediated cytotoxicity

1 reference

8 April 2019

Expression of adhesion molecules on mature cholangiocytes in canal of Hering and bile ductules in wedge biopsy samples of primary biliary cirrhosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

1 reference

8 April 2019

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

extracellular matrix organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

1 reference

8 April 2019

acute inflammatory response to antigenic stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

hearing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to alkaloid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to gonadotropin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

positive regulation of cellular extravasation

1 reference

8 April 2019

Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

positive regulation of GTPase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

regulation of cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

3 references

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

31 October 2017

VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05362&geneProductId=UniProtKB:P05362

cell adhesion mediated by integrin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

8 April 2019

Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

positive regulation of vasoconstriction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to interleukin-1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to nutrient levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

negative regulation of calcium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

regulation of cell shape

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

membrane to membrane docking

1 reference

8 April 2019

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

ovarian follicle development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

regulation of immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

1 reference

8 April 2019

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

regulation of ruffle assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

viral entry into host cell

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

1 reference

8 April 2019

cellular response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

leukocyte migration

1 reference

8 April 2019

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to glucose stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

response to insulin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to interferon-gamma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to interleukin-6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to dexamethasone stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

establishment of endothelial intestinal barrier

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

positive regulation of leukocyte adhesion to vascular endothelial cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to leukemia inhibitory factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cytokine-mediated signaling pathway

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

1 reference

8 April 2019

T cell extravasation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

cellular response to amyloid-beta

1 reference

8 April 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05362

https://docs.openalex.org/download-snapshot/snapshot-data-format

Gene Atlas image

PBB GE ICAM1 202638 s at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

D018799

subject named as

Intercellular Adhesion Molecule-1

0 references

MeSH tree code

D12.776.395.550.200.450

0 references

D12.776.543.550.200.450

0 references

D23.050.301.350.450

0 references

D09.400.430.890.200.450

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023