Mechanisms of multidrug resistance and implications for therapy. (Q39602850)

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scientific article published on March 1988

Language	Label	Description	Also known as
English	Mechanisms of multidrug resistance and implications for therapy.	scientific article published on March 1988

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

Mechanisms of multidrug resistance and implications for therapy. (English)

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

author name string

T Tsuruo

1

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

publication date

1 March 1988

2 references

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

3 April 2019

Japanese Journal of Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

79

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

3

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

285-296

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Establishment and properties of vincristine-resistant human myelogenous leukemia K562.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Multidrug-resistance phenotype in Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Drug resistance in Chinese hamster lung and mouse tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Co-Amplification of Double Minute Chromosomes, Multiple Drug Resistance, and Cell Surface P-Glycoprotein in DNA-Mediated Transformants of Mouse Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response

1 reference

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15 June 2018

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1 reference

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15 June 2018

Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Pleiotropic drug resistance and gene amplification in a SEWA mouse tumor cell line. Complex relations revealed by drug uptake data, and lipid and protein analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

In situ selection of a human rhabdomyosarcoma resistant to vincristine with altered beta-tubulins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Calcium, calmodulin, and protein content of adriamycin-resistant and -sensitive murine leukemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Monoclonal antibodies to glycoproteins of Vinca alkaloid-resistant human leukemic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Isolation and characterization of an anthracycline-resistant human leukemic cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and in isolated clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

DNA-mediated transfer and cloning of a human multidrug-resistant gene of adriamycin-resistant myelogenous leukemia K562.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

The effect of verapamil on the pharmacokinetics of adriamycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Isolation and expression of a complementary DNA that confers multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Expression of a multidrug-resistance gene in human tumors and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Amplification and expression of genes associated with multidrug resistance in mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Mechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

In vivo characteristics of resistance and cross-resistance of an adriamycin-resistant subline of P388 leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Mutants of Chinese hamster ovary (CHO) cells with altered colcemid-binding affinity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Resistance and cross-resistance of cultured leukemia P388 cells to vincristine, adriamycin, adriamycin analogs, and actinomycin D

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Pleiotropic phenotype of colchicine-resistant CHO cells: cross-resistance and collateral sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

15 June 2018

Mixed-function oxidase enzymes in adriamycin-sensitive and resistant sublines of P-388 leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

High calcium content of pleiotropic drug-resistant P388 and K562 leukemia and Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917488

21 August 2018

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.1988.TB01588.X

21 January 2018

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.1988.TB01588.X

21 January 2018

Identifiers

10.1111/J.1349-7006.1988.TB01588.X

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 June 2018

http://europepmc.org/abstract/PMC/5917488

ResearchGate publication ID

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