An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis. (Q39699129)

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Language	Label	Description	Also known as
English	An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis.	scientific article

Statements

instance of

scholarly article

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Europe PubMed Central

PMC publication ID

140780

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14 September 2017

title

An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis. (English)

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Europe PubMed Central

PMC publication ID

140780

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14 September 2017

author name string

Mark T Heise

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1

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Laura J White

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2

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Dennis A Simpson

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3

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140780

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Christopher Leonard

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4

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140780

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Kristen A Bernard

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5

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140780

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Rick B Meeker

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6

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140780

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Robert E Johnston

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7

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140780

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14 September 2017

publication date

1 January 2003

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14 September 2017

published in

Journal of Virology

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14 September 2017

volume

77

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14 September 2017

issue

2

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140780

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page(s)

1149-1156

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140780

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14 September 2017

cites work

Role of alpha/beta interferon in Venezuelan equine encephalitis virus pathogenesis: effect of an attenuating mutation in the 5' untranslated region

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PubMed Central

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14 September 2017

Sindbis-group alphavirus replication in periosteum and endosteum of long bones in adult mice

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14 September 2017

Replicase complex genes of Semliki Forest virus confer lethal neurovirulence

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PubMed Central

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14 September 2017

A single amino acid change in nsP1 attenuates neurovirulence of the Sindbis-group alphavirus S.A.AR86.

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PubMed Central

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14 September 2017

A single nucleotide change in the 5' noncoding region of Sindbis virus confers neurovirulence in rats.

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PubMed Central

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14 September 2017

Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome

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PubMed Central

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14 September 2017

RNA helicase activity of Semliki Forest virus replicase protein NSP2.

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14 September 2017

Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells.

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PubMed Central

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14 September 2017

Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor.

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PubMed Central

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14 September 2017

Amino acid changes in the Sindbis virus E2 glycoprotein that increase neurovirulence improve entry into neuroblastoma cells

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PubMed Central

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14 September 2017

Genetic determinants of Sindbis virus neuroinvasiveness

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PubMed Central

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14 September 2017

Deduced consensus sequence of Sindbis virus strain AR339: mutations contained in laboratory strains which affect cell culture and in vivo phenotypes

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PubMed Central

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14 September 2017

Roles of nonstructural polyproteins and cleavage products in regulating Sindbis virus RNA replication and transcription

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PubMed Central

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14 September 2017

Assembly of functional Sindbis virus RNA replication complexes: requirement for coexpression of P123 and P34

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PubMed Central

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14 September 2017

Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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14 September 2017

Comparison of the effects of Sindbis virus and Sindbis virus replicons on host cell protein synthesis and cytopathogenicity in BHK cells

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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14 September 2017

The alphaviruses: gene expression, replication, and evolution

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PubMed Central

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14 September 2017

Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses

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PubMed Central

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14 September 2017

Inhibition of Interjacent Ribonucleic Acid (26 S ) Synthesis in Cells Infected by Sindbis Virus

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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14 September 2017

Processing the nonstructural polyproteins of Sindbis virus: study of the kinetics in vivo by using monospecific antibodies

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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14 September 2017

Molecular basis of Sindbis virus neurovirulence in mice

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PubMed Central

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14 September 2017

Processing the nonstructural polyproteins of sindbis virus: nonstructural proteinase is in the C-terminal half of nsP2 and functions both in cis and in trans

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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14 September 2017

Functional defects of RNA-negative temperature-sensitive mutants of Sindbis and Semliki Forest viruses

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PubMed Central

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14 September 2017

Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus- and plus-strand RNA synthesis

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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25 September 2017

Fatal Sindbis virus infection of neonatal mice in the absence of encephalitis

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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25 September 2017

Evidence that Sindbis virus NSP2 is an autoprotease which processes the virus nonstructural polyprotein

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140780

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25 September 2017

Identifiers

DOI

10.1128/JVI.77.2.1149-1156.2003

1 reference

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Europe PubMed Central

PMC publication ID

140780

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14 September 2017

PMC publication ID

140780

1 reference

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Europe PubMed Central

PMC publication ID

140780

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14 September 2017

PubMed publication ID

12502831

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stated in

Europe PubMed Central

PMC publication ID

140780

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14 September 2017

 

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