cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control. (Q38335069)

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Language	Label	Description	Also known as
English	cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control.	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control. (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

author name string

Sattlegger E

1

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Hinnebusch AG

2

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Barthelmess IB

3

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

publication date

1 August 1998

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

273

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

32

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

20404-20416

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

The cross-pathway control gene of Neurospora crassa, cpc-1, encodes a protein similar to GCN4 of yeast and the DNA-binding domain of the oncogene v-jun-encoded protein

1 reference

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The Aspergillus niger GCN4 homologue, cpcA, is transcriptionally regulated and encodes an unusual leucine zipper

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Cloning and Characterization of a General Amino Acid Control Transcriptional Activator from the Chestnut Blight FungusCryphonectria parasitica

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Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase

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Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

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21 January 2018

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

1 reference

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21 January 2018

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

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Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase

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Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase

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PKR: a new name and new roles.

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The regulation of the protein kinase PKR by RNA.

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Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase

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eIF-2 kinases: regulators of general and gene-specific translation initiation

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Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

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The cpc-2 gene of Neurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility.

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Efficient cloning of genes of Neurospora crassa

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Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurospora crassa and its use as a dominant selectable marker

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High-efficiency electro-transformation of Escherichia coli with DNA from ligation mixtures

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High efficiency electroporation of ligated DNA into bacteria

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Basic local alignment search tool

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A comprehensive set of sequence analysis programs for the VAX

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cpc-1, the general regulatory gene for genes of amino acid biosynthesis in Neurospora crassa, is differentially expressed during the asexual life cycle

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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21 January 2018

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

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21 January 2018

Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases

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The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase

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Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase

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Isolation and Analysis of Mutated Histidyl-tRNA Synthetases fromEscherichia coli

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Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp)

1 reference

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Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases

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Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases

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Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

1 reference

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An efficient method for gene disruption in Neurospora crassa.

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A tRNA identity switch mediated by the binding interaction between a tRNA anticodon and the accessory domain of a class II aminoacyl-tRNA synthetase

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Translational regulation in response to changes in amino acid availability in Neurospora crassa.

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Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control

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Role of the extra G-C pair at the end of the acceptor stem of tRNA(His) in aminoacylation

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Enzymatic aminoacylation of an eight-base-pair microhelix with histidine

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Strategy for RNA recognition by yeast histidyl-tRNA synthetase

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Compilation of tRNA sequences and sequences of tRNA genes

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Evidence for translational regulation of the activator of general amino acid control in yeast

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A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae

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Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

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Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1 reference

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1 reference

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Calcium-dependent bacteriophage DNA infection

1 reference

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Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

1 reference

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21 January 2018

Identifiers

10.1074/JBC.273.32.20404

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

ResearchGate publication ID

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