Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation (Q38355051)

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English	Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

2 September 2017

Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation (English)

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Europe PubMed Central

PMC publication ID

2 September 2017

Mathew L Coleman

object named as

Mathew L Coleman

1

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Michael F. Olson

object named as

Michael F Olson

3

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author name string

Christopher J Marshall

2

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Europe PubMed Central

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2 September 2017

language of work or name

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publication date

1 May 2003

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Europe PubMed Central

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2 September 2017

The EMBO Journal

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Europe PubMed Central

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2 September 2017

22

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Europe PubMed Central

PMC publication ID

2 September 2017

9

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Europe PubMed Central

PMC publication ID

2 September 2017

2036-2046

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Europe PubMed Central

PMC publication ID

2 September 2017

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC156064/fullTextXML

based on heuristic

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A system for stable expression of short interfering RNAs in mammalian cells

1 reference

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Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts

1 reference

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

1 reference

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A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

1 reference

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Analysis of the transcriptional program induced by Raf in epithelial cells

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Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators

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Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

1 reference

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

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The ubiquitin system

1 reference

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CCAAT/Enhancer Binding Protein α Regulates p21 Protein and Hepatocyte Proliferation in Newborn Mice

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Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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1 reference

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ras oncogenes in human cancer: a review

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1 reference

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Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors

1 reference

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

1 reference

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High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1

1 reference

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Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

1 reference

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p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export

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Inhibitory effect of p21 in MCF-7 cells is overcome by its coordinated stabilization with D-type cyclins

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Ras enhances Myc protein stability.

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1 reference

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Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.

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1 reference

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1 reference

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1 reference

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1 reference

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Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein

1 reference

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Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12727871

12 December 2020

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Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12727871

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Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21

1 reference

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Transcriptional Regulation of the p21(WAF1/CIP1)Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12727871

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Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells

1 reference

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Identifiers

10.1093/EMBOJ/CDG189

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

ResearchGate publication ID

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